Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4933138 | 0.73 | HDAC6 (0.53) | HDAC6ALOX15HTTSMN1; SMN2CSNK2A2 | |
| SCHEMBL16024218 | 0.72 | MKNK1 (0.45) | MKNK1SMN1; SMN2POLB | |
| SCHEMBL17707701 | 0.69 | ADORA2A (0.36) | MKNK1HTTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4929694 | 0.67 | HDAC6 (0.53) | HDAC6ALOX15HTTSMN1; SMN2MEN1 | |
| SCHEMBL22094957 | 0.66 | ADORA3 (0.47) | HDAC6MKNK1KDM4ENOTUM | |
| SCHEMBL25211649 | 0.64 | HDAC6 (0.45) | HDAC6ALOX15HTTSMN1; SMN2 | |
| SCHEMBL8658335 | 0.63 | AKR1A1 (0.55) | — | |
| SCHEMBL24331734 | 0.63 | AKR1B1 (0.52) | HDAC6ALOX15HTTSMN1; SMN2KDM4E | |
| SCHEMBL1514591 | 0.62 | HDAC6 (1.00) | HDAC6ALOX15HTTSMN1; SMN2MEN1 | |
| SCHEMBL28979179 | 0.61 | HDAC6 (0.50) | HDAC6ALOX15HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964656-A1 | SUBSTITUTED THIAZOLOPYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135480-A1 | SUBSTITUTED THIAZOLOPYRIMIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-09-12 | — | — | WO | disclosed |