Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | QPCT | Q16769 | 2/20 | 0.52 |
| ▸ | QPCTL | Q9NXS2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | SI | P14410 | 3/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1595944 | 0.82 | QPCT (0.52) | ALDH1A1SMN1; SMN2LMNAQPCTQPCTL | |
| SCHEMBL11369352 | 0.78 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL31165776 | 0.78 | BACE1 (0.46) | ALDH1A1SMN1; SMN2QPCTQPCTLKDM4E | |
| SCHEMBL25269484 | 0.78 | BACE1 (0.46) | ALDH1A1SMN1; SMN2QPCTQPCTLKDM4E | |
| SCHEMBL20916075 | 0.77 | GSK3B (0.53) | GSK3BDYRK1AWNT1 | |
| SCHEMBL10284642 | 0.76 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNAQPCTQPCTL | |
| SCHEMBL1594955 | 0.76 | KDM4E (0.57) | ALDH1A1SMN1; SMN2LMNAQPCTQPCTL | |
| SCHEMBL7233066 | 0.74 | MGAM (0.58) | ALDH1A1SMN1; SMN2LMNAQPCTQPCTL | |
| SCHEMBL11339097 | 0.73 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNAQPCTQPCTL | |
| SCHEMBL1594544 | 0.71 | EGFR (0.53) | ALDH1A1SMN1; SMN2LMNAQPCTQPCTL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809282-B1 | THIADIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2013-01-09 | — | — | EP | disclosed |
| US-7919514-B2 | Protein kinase B inhibitors; anticarcinogenic, antiinflammatory and antiproliferative agents; metabolic disorders; 3-(3-fluoro-phenyl)-N-[5-(3-methyl-1H-indazol-5-yl)-[1,3,4]thiadiazol-2-yl]-propane-1,2-diamine and derivatives | AMGEN INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7700636-B2 | Thiadiazole compounds and methods of use | AMGEN INC. (US) | 2010-04-20 | — | — | US | disclosed |
| CN-101389335-A | Thiadiazole compounds and methods of use. | AMGEN INC (US) | 2009-03-18 | — | — | CN | disclosed |
| US-20080269243-A1 | Thiadiazole compounds and methods of use | AMGEN INC. (US) | 2008-10-30 | — | — | US | disclosed |
| US-20080255145-A1 | Thiadiazole compounds and methods of use | AMGEN INC. (US) | 2008-10-16 | — | — | US | disclosed |
| US-7354944-B2 | Thiadiazole compounds and methods of use | AMGEN INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-20060154961-A1 | Thiadiazole compounds and methods of use | AMGEN INC. | 2006-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255145-A1 | Thiadiazole compounds and methods of use | PDK2, PDK1, PANK2 | ALDH1A1 2285/4885SMN1; SMN2 4487/4885LMNA 4376/4885 |
| US-20080269243-A1 | Thiadiazole compounds and methods of use | PDK2, PDK1, PANK2 | ALDH1A1 2285/4885SMN1; SMN2 4487/4885LMNA 4376/4885 |
| US-20060154961-A1 | Thiadiazole compounds and methods of use | PDK2, PDK1, PANK2 | ALDH1A1 2285/4885SMN1; SMN2 4487/4885LMNA 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.