Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.50 |
| ▸ | PDE8B | O95263 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29049972 | 0.89 | PTPN1 (0.60) | TSHRNPC1LMNAALDH1A1NPBWR1 | |
| SCHEMBL370942 | 0.85 | LMNA (0.80) | TSHRNPC1LMNAALDH1A1UCHL1 | |
| SCHEMBL28327863 | 0.82 | NPBWR1 (0.50) | TSHRNPC1LMNANPBWR1PDE8B | |
| SCHEMBL174541 | 0.81 | TSHR (0.76) | TSHRNPC1LMNAALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL4102414 | 0.80 | NPBWR1 (0.52) | TSHRNPBWR1PDE8BALOX15L3MBTL1 | |
| SCHEMBL1801455 | 0.80 | NPBWR1 (0.54) | TSHRNPC1LMNAALDH1A1NPBWR1 | |
| SCHEMBL30050755 | 0.79 | PDE8B (0.46) | TSHRNPC1NPBWR1PDE8BALOX15 | |
| SCHEMBL1491119 | 0.79 | TSHR (0.67) | TSHRNPC1LMNAALDH1A1NPBWR1 | |
| SCHEMBL16014600 | 0.78 | TSHR (0.44) | TSHRALDH1A1NPBWR1PDE8BALOX15 | |
| Sulfuric Acid SCHEMBL2923461 | 0.78 | NPBWR1 (0.50) | TSHRNPC1LMNANPBWR1PDE8B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143220-B | Pyrazole derivatives | 豪夫迈·罗氏有限公司 | 2018-06-22 | — | — | CN | disclosed |
| US-9694012-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9694012-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9694012-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| EP-2964646-B1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-04-19 | — | — | EP | disclosed |
| EP-2964646-B1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-04-19 | — | — | EP | disclosed |
| US-20170035769-A1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170035769-A1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170035769-A1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-02-09 | — | — | US | disclosed |
| US-9512132-B2 | Pyrazole compounds as CB2 agonists | HOFFMANN-LA ROCHE INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-9512132-B2 | Pyrazole compounds as CB2 agonists | HOFFMANN-LA ROCHE INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-9512132-B2 | Pyrazole compounds as CB2 agonists | HOFFMANN-LA ROCHE INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | SUNOVION PHARMACEUTICALS INC (US) | 2016-03-24 | — | — | US | disclosed |
| EP-2964646-A1 | NOVEL PYRAZOL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-01-13 | — | — | EP | disclosed |
| US-20150376192-A1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-12-31 | — | — | US | disclosed |
| US-20150376192-A1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-12-31 | — | — | US | disclosed |
| US-20150376192-A1 | NOVEL PYRAZOL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-12-31 | — | — | US | disclosed |
| WO-2014135507-A1 | NOVEL PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-12 | — | — | WO | disclosed |
| WO-2014135507-A1 | NOVEL PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376192-A1 | NOVEL PYRAZOL DERIVATIVES | CYP3A43, ADRB3, UGT1A3 | TSHR 1771/4885NPC1 406/4885LMNA 2981/4885 |
| US-20160083391-A1 | TRICYCLIC PIPERAZINE DERIVATIVE | PDE3A, PDE5A, PDE2A | TSHR 3962/4885NPC1 2829/4885LMNA 2962/4885 |
| US-20170035769-A1 | NOVEL PYRAZOL DERIVATIVES | CYP3A43, ADRB3, UGT1A3 | TSHR 1771/4885NPC1 406/4885LMNA 2981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.