Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16015140 | 0.89 | LIPE (0.44) | TSHRSMN1; SMN2ALDH1A1LIPEGAA | |
| SCHEMBL1334012 | 0.88 | KMT2A (0.48) | SMN1; SMN2ALDH1A1GAALMNAGFER | |
| SCHEMBL12124068 | 0.88 | KMT2A (0.48) | SMN1; SMN2ALDH1A1GAALMNAGFER | |
| SCHEMBL16015131 | 0.86 | LIPE (0.46) | TSHRSMN1; SMN2ALDH1A1LIPELMNA | |
| SCHEMBL16015134 | 0.85 | LIPE (0.44) | TSHRSMN1; SMN2LIPENPC1RAB9A | |
| SCHEMBL16015141 | 0.85 | ALDH1A1 (0.53) | TSHRSMN1; SMN2ALDH1A1LIPEGAA | |
| SCHEMBL16015132 | 0.84 | POLB (0.52) | TSHRALDH1A1LIPEPOLBLMNA | |
| SCHEMBL12124090 | 0.84 | LIPE (0.44) | TSHRSMN1; SMN2ALDH1A1LIPEHPGD | |
| SCHEMBL1335621 | 0.84 | LIPE (0.44) | TSHRSMN1; SMN2ALDH1A1LIPEHPGD | |
| SCHEMBL16015146 | 0.82 | LIPE (0.43) | TSHRSMN1; SMN2LIPENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829027-B2 | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-09 | — | — | US | disclosed |