SCHEMBL16015685

SCHEMBL16015685

O=C(NC(=O)c1c(F)cccc1F)Nc1cc(C(F)(F)F)cc(CF)c1Cl

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
USP2 O75604 1/20 0.48
MAPT P10636 1/20 0.48
ALOX15 P16050 1/20 0.48
TLR7 Q9NYK1 2/20 0.47
TRPA1 O75762 3/20 0.45
GAA P10253 1/20 0.45
CYP1A2 P05177 1/20 0.44
ATM Q13315 1/20 0.43
IL2 P60568 2/20 0.43
TLR8 Q9NR97 4/20 0.41
TRPV1 Q8NER1 1/20 0.41
GPR35 Q9HC97 2/20 0.40
P2RX1 P51575 1/20 0.40
P2RX7 Q99572 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29436079 0.87 MEN1 (0.58) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL65405 0.87 MEN1 (0.58) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL13036826 0.79 MEN1 (0.50) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL7748786 0.78 TLR7 (0.49) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL10427572 0.77 MEN1 (0.59) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL10777482 0.77 MEN1 (0.59) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL352658 0.76 MEN1 (0.54) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL29608194 0.76 MEN1 (0.54) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL7752523 0.75 TRPV1 (0.57) MEN1KMT2AMAPTTLR7GAA
SCHEMBL7746023 0.74 KMT2A (0.74) MEN1KMT2AUSP2MAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8828907-B2 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-09 US disclosed