SCHEMBL352658

SCHEMBL352658

O=C(NC(=O)c1c(F)cccc1F)Nc1ccc(C(F)(F)F)cc1F

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
ATM Q13315 1/20 0.50
IL2 P60568 2/20 0.49
USP2 O75604 1/20 0.49
MAPT P10636 1/20 0.49
ALOX15 P16050 1/20 0.49
TRPA1 O75762 3/20 0.46
TLR7 Q9NYK1 2/20 0.46
KIF11 P52732 1/20 0.46
CYP1A2 P05177 1/20 0.45
TRPV1 Q8NER1 1/20 0.45
P2RY1 P47900 2/20 0.43
GAA P10253 1/20 0.43
TLR8 Q9NR97 2/20 0.42
IGF1R P08069 1/20 0.42
GRIK1 P39086 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29608194 1.00 MEN1 (0.54) MEN1KMT2AATMIL2USP2
SCHEMBL10606310 0.90 MEN1 (0.52) MEN1KMT2AATMIL2USP2
SCHEMBL9728803 0.90 MEN1 (0.52) MEN1KMT2AATMIL2USP2
SCHEMBL9729612 0.89 KIF11 (0.46) MEN1KMT2AKIF11CYP1A2TRPV1
SCHEMBL9728378 0.87 MEN1 (0.50) MEN1KMT2AATMIL2USP2
SCHEMBL9504696 0.83 MEN1 (0.49) MEN1KMT2AATMIL2USP2
SCHEMBL8657856 0.83 KMT2A (0.59) MEN1KMT2AATMMAPTGAA
Flufenoxuron SCHEMBL27798 0.83 MEN1 (0.52) MEN1KMT2AIL2USP2MAPT
SCHEMBL31499167 0.83 TLR8 (0.51) MEN1KMT2AIL2USP2MAPT
SCHEMBL8623087 0.83 MEN1 (0.49) MEN1KMT2AATMIL2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 340 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9949953-B2 Topical compositions comprising fipronil and permethrin and methods of use MERIAL INC. (US) 2018-04-24 US claimed
US-20160361297-A1 Topical Compositions Comprising Fipronil and Permethrin and Methods of Use MERIAL, INC. (US) 2016-12-15 US claimed
US-9066515-B2 Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz MERIAL, INC. (US) 2015-06-30 US claimed
US-20140024693-A1 TOPICAL COMPOSITION KEYBANK NATIONAL ASSOCIATION, AS COLLATERAL AGENT 2014-01-23 US claimed
US-20130065930-A1 TOPICAL COMPOSITION OMNIPHARM LIMITED (GB) 2013-03-14 US claimed
US-20130023490-A1 TOPICAL FORMULATIONS COMPRISING 1-N-ARYLPYRAZOLE DERIVATIVES AND AMITRAZ MERIAL, INC. 2013-01-24 US claimed
EP-2395842-A2 TOPICAL COMPOSITION CIPLA LIMITED (IN) 2011-12-21 EP claimed
WO-2010092355-A2 TOPICAL COMPOSITION CIPLA LIMITED (IN) 2010-08-19 WO claimed
US-20020090387-A1 Insecticidal combination to control mammal fleas in particular fleas in particular fleas on cats and dogs JEANNIN PHILIPPE (FR) 2002-07-11 US claimed
US-6096329-A Insecticidal combination to control mammal fleas, in particular fleas on cats and dogs MERIAL (FR) 2000-08-01 US claimed
US-5567429-A PESTICIDES COMPRISING AT LEAST ONE INSECT GROWTH REGULATOR POLYFLUOROPHENYL-ACYLUREA COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-10-22 US claimed
US-5300293-A Mixture of antigrowth agent and dextrin SUMITOMO CHEMICAL CO., LTD. (JP) 1994-04-05 US claimed
US-5096710-A Cockroaches, juvenile hormone or chitin synthesis inhibitor, dextrin, plant oil SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-03-17 US claimed
US-4782090-A Benzoyl(thio)urea pesticides BAYER AKTIENGESELLSCHAFT (DE) 1988-11-01 US claimed
JP-7187924-A None JP disclosed
US-20250331520-A1 HARMFUL ORGANISM CONTROL COMPOSITION NIPPON SODA CO., LTD. (JP) 2025-10-30 US disclosed
CN-112996788-B Anthelmintic heterocyclic compounds 勃林格殷格翰动物保健美国公司 2024-07-16 CN disclosed
EP-0246061-B1 A BENZOYLUREA DERIVATIVE AND ITS PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-03-18 EP disclosed
EP-0431468-A1 A poison bait for control for harmful insects SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-06-12 EP disclosed
US-4782090-A Benzoyl(thio)urea pesticides BAYER AKTIENGESELLSCHAFT (DE) 1988-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130023490-A1 TOPICAL FORMULATIONS COMPRISING 1-N-ARYLPYRAZOLE DERIVATIVES AND AMITRAZ MGAT2, MGAT1, MIF MEN1 3974/4885KMT2A 2162/4885ATM 3057/4885
US-20160361297-A1 Topical Compositions Comprising Fipronil and Permethrin and Methods of Use FASN, MTPN, FAAH MEN1 2044/4885KMT2A 2383/4885ATM 4537/4885
US-20250331520-A1 HARMFUL ORGANISM CONTROL COMPOSITION OLA1, SOD1, GLB1 MEN1 676/4885KMT2A 1739/4885ATM 3424/4885
US-20020090387-A1 Insecticidal combination to control mammal fleas in particular fleas in particular fleas on cats and dogs CUTA, IGF1R, FIBP MEN1 2712/4885KMT2A 2650/4885ATM 4462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.