SCHEMBL7748786

SCHEMBL7748786

O=C(NC(=O)c1c(Cl)cccc1Cl)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 2/20 0.49
MEN1 O00255 4/20 0.48
KMT2A Q03164 4/20 0.48
KDR P35968 1/20 0.46
GAA P10253 2/20 0.46
GPR35 Q9HC97 3/20 0.45
MAPT P10636 3/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
TMPRSS4 Q9NRS4 2/20 0.43
TYK2 P29597 1/20 0.43
P2RX1 P51575 1/20 0.43
P2RX4 Q99571 1/20 0.43
P2RX7 Q99572 1/20 0.43
TLR8 Q9NR97 3/20 0.43
USP2 O75604 1/20 0.42
ALOX15 P16050 1/20 0.42
ALDH1A1 P00352 2/20 0.41
KCNH2 Q12809 1/20 0.41
TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL65405 0.90 MEN1 (0.58) TLR7MEN1KMT2AGAAGPR35
SCHEMBL9117160 0.90 TLR7 (0.47) TLR7MEN1KMT2AKDRGAA
SCHEMBL29436079 0.90 MEN1 (0.58) TLR7MEN1KMT2AGAAGPR35
SCHEMBL7752690 0.88 KDM4E (0.53) MEN1KMT2AKDRGAAGPR35
SCHEMBL7752523 0.82 TRPV1 (0.57) TLR7MEN1KMT2AGAAGPR35
SCHEMBL7748808 0.81 SMN1; SMN2 (0.52) GAAGPR35SMN1; SMN2TMPRSS4TP53
SCHEMBL8011999 0.81 MEN1 (0.48) TLR7MEN1KMT2AKDRGAA
SCHEMBL7748816 0.79 NNMT (0.43) MEN1KMT2AGAAGPR35MAPT
SCHEMBL10427572 0.79 MEN1 (0.59) TLR7MEN1KMT2AGAAMAPT
SCHEMBL10777482 0.79 MEN1 (0.59) TLR7MEN1KMT2AGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP claimed
EP-0912502-B1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME DONGBU HANNONG CHEMICAL CO LTD (KR) 2001-01-17 EP disclosed
US-6022882-A POTENT GROWTH-RETARDING ACTIVITY AGAINST PESTS DONGBU HANNONG CHEMICAL CO., LTD. (KR) 2000-02-08 US disclosed
EP-0912502-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME Hanwha Corporation (KR) 1999-05-06 EP disclosed
WO-1998000394-A1 2-CHLORO-3,5-BIS(TRIFLUOROMETHYL)PHENYL BENZOYL UREA DERIVATIVE AND PROCESS FOR PREPARING THE SAME HANWHA CORPORATION (KR) 1998-01-08 WO disclosed