Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.41 |
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.37 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28312340 | 0.84 | KAT2B (0.47) | KAT2BALDH1A1 | |
| SCHEMBL18753182 | 0.84 | ESR1 (0.38) | TAAR1KAT2BMAPT | |
| SCHEMBL28292260 | 0.82 | TAAR1 (0.50) | TAAR1CTBP2CHRM2PTGS1PTGS2 | |
| SCHEMBL17771887 | 0.81 | ALDH1A1 (0.45) | KAT2BHTTHPGDALDH1A1 | |
| SCHEMBL14024290 | 0.81 | KAT2B (0.35) | KAT2B | |
| SCHEMBL17553821 | 0.79 | KAT2B (0.45) | KAT2BMAPT | |
| SCHEMBL16433534 | 0.78 | TAAR1 (0.47) | TAAR1KAT2BMAPTKMT2AMEN1 | |
| SCHEMBL15290182 | 0.78 | PYCR1 (0.39) | TAAR1KAT2BMAPTKMT2AMEN1 | |
| SCHEMBL23754928 | 0.77 | CYP1A2 (0.39) | KAT2BTSHRKMT2AMEN1LMNA | |
| SCHEMBL297196 | 0.77 | TAAR1 (0.52) | TAAR1ACAT2CTBP2CHRM2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12473263-B2 | Bicyclic inhibitors of CBX chromodomains | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2025-11-18 | — | — | US | disclosed |
| US-20220402880-A1 | BICYCLIC INHIBITORS OF CBX CHROMODOMAINS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-12-22 | — | — | US | disclosed |
| EP-4034250-A1 | BICYCLIC INHIBITORS OF CBX CHROMODOMAINS | Icahn School of Medicine at Mount Sinai (US) | 2022-08-03 | — | — | EP | disclosed |
| EP-3896062-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-10-20 | — | — | EP | disclosed |
| WO-2021061801-A1 | BICYCLIC INHIBITORS OF CBX CHROMODOMAINS | ICAHN SCHOOL OF MEDICINE AT MT. SINAI (US) | 2021-04-01 | — | — | WO | disclosed |
| EP-3038612-B1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-07-29 | — | — | EP | disclosed |
| CN-107602570-B | Method for synthesizing nitrogen-containing multi-membered heterocyclic compound | 暨南大学 | 2020-07-03 | — | — | CN | disclosed |
| US-10351511-B2 | Cyclic vinylogous amides as bromodomain inhibitors | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-07-16 | — | — | US | disclosed |
| CN-105873577-B | Cycloalkenylamides as bromodomain inhibitors | 西奈山伊坎医学院 | 2019-06-18 | — | — | CN | disclosed |
| CN-109096211-A | A kind of preparation method of polysubstituted triazole derivatives | 华侨大学 | 2018-12-28 | — | — | CN | disclosed |
| US-20170233405-A1 | MAX BINDERS AS MYC MODULATORS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2017-08-17 | — | — | US | disclosed |
| EP-3135668-A1 | NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2017-03-01 | — | — | EP | disclosed |
| CN-105873577-A | Cycloalkenylamides as bromodomain inhibitors | 西奈山伊坎医学院 | 2016-08-17 | — | — | CN | disclosed |
| US-20160200666-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-07-14 | — | — | US | disclosed |
| EP-3038612-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | Icahn School of Medicine at Mount Sinai (US) | 2016-07-06 | — | — | EP | disclosed |
| WO-2015031824-A9 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-06-16 | — | — | WO | disclosed |
| WO-2015163427-A1 | NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND | 田辺三菱製薬株式会社 | 2015-10-29 | — | — | WO | disclosed |
| WO-2015031824-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2015-03-05 | — | — | WO | disclosed |
| WO-2015007613-A1 | O-ALKYL TRIAZOLYL CARBAMATES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE (FAAH) | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2015-01-22 | — | — | WO | disclosed |
| EP-2774940-A1 | METHOD FOR PRODUCING CONJUGATED POLYMER, CONJUGATED POLYMER, PHOTOELECTRIC CONVERSION ELEMENT, SOLAR CELL, AND SOLAR CELL MODULE | Mitsubishi Chemical Corporation (JP) | 2014-09-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473263-B2 | Bicyclic inhibitors of CBX chromodomains | CBX2, CBX3, CBX6 | TAAR1 2357/4885KAT2B 1423/4885ACAT2 2229/4885 |
| US-20160200666-A1 | CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS | BRD1, BRD4, BRDT | TAAR1 3572/4885KAT2B 25/4885ACAT2 30/4885 |
| US-10351511-B2 | Cyclic vinylogous amides as bromodomain inhibitors | BRD1, BRD4, BRDT | TAAR1 3572/4885KAT2B 25/4885ACAT2 30/4885 |
| US-20170233405-A1 | MAX BINDERS AS MYC MODULATORS AND USES THEREOF | MYC, MYCBP, MYCBP2 | TAAR1 4605/4885KAT2B 1003/4885ACAT2 1407/4885 |
| US-20220402880-A1 | BICYCLIC INHIBITORS OF CBX CHROMODOMAINS | CBX2, CBX3, CBX7 | TAAR1 4411/4885KAT2B 546/4885ACAT2 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.