Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203524 | 0.79 | ALDH1A1 (0.41) | HTR6TDP1MAPK1LMNAALDH1A1 | |
| SCHEMBL19832553 | 0.79 | HTR6 (0.33) | HTR6TDP1MAPK1LMNAALDH1A1 | |
| SCHEMBL20724163 | 0.78 | IDO1 (0.39) | PKMPTGS2RAB9APTGS1KDM4E | |
| SCHEMBL1020748 | 0.78 | HTR6 (0.36) | HTR6TDP1MAPK1LMNAALDH1A1 | |
| SCHEMBL1020357 | 0.76 | SMN1; SMN2 (0.39) | HTR6TDP1MAPK1LMNAALDH1A1 | |
| SCHEMBL16018751 | 0.75 | HTR6 (0.38) | HTR6TDP1MAPK1LMNAALDH1A1 | |
| SCHEMBL16016394 | 0.73 | HDAC1 (0.44) | LMNAHPGDGAAMAPTRAB9A | |
| SCHEMBL8388657 | 0.71 | — | — | |
| SCHEMBL19832429 | 0.71 | HTR6 (0.38) | HTR6TDP1MAPK1LMNAALDH1A1 | |
| SCHEMBL1020888 | 0.71 | TAAR1 (0.44) | HTR6TDP1MAPK1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2774928-B1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE-INHIBITING ACTIVITY | SHIONOGI & CO (JP) | 2017-08-30 | — | — | EP | disclosed |
| EP-2774928-A1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2014-09-10 | — | — | EP | disclosed |