Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 15/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 15/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16020558 | 0.89 | STIM1 (0.50) | ABCC8KCNJ11STIM1ORAI1SCN9A | |
| SCHEMBL14881337 | 0.88 | LMNA (0.53) | STIM1ORAI1LMNASCN9A | |
| SCHEMBL16017233 | 0.84 | STIM1 (0.44) | STIM1ORAI1SCN9A | |
| SCHEMBL16020555 | 0.81 | STIM1 (0.49) | ABCC8KCNJ11STIM1ORAI1 | |
| SCHEMBL16019818 | 0.80 | CYP1A2 (0.46) | LMNA | |
| SCHEMBL16019813 | 0.80 | ALDH1A1 (0.44) | STIM1ORAI1SCN9A | |
| SCHEMBL14881315 | 0.78 | STIM1 (0.49) | ABCC8KCNJ11STIM1ORAI1 | |
| SCHEMBL12181712 | 0.78 | LMNA (0.51) | STIM1ORAI1LMNA | |
| SCHEMBL15986065 | 0.78 | LMNA (0.51) | ORAI1LMNA | |
| SCHEMBL16017275 | 0.78 | RAB9A (0.53) | STIM1ORAI1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ABCC8 1186/4885KCNJ11 163/4885STIM1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.