Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | PPP3CB | P16298 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936992 | 0.93 | CTSB (0.48) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL7937868 | 0.91 | CTSB (0.43) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL9978730 | 0.88 | CTSB (0.50) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL2215312 | 0.87 | CTSB (0.48) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL8242872 | 0.87 | CTSB (0.48) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL1688355 | 0.87 | CTSB (0.53) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL17212947 | 0.86 | CTSB (0.44) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL1101688 | 0.86 | CTSS (0.44) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL12383126 | 0.86 | CTSB (0.35) | CTSSCTSBPPP3CBABCC1ABCC2 | |
| SCHEMBL13336994 | 0.85 | CTSS (0.43) | CTSSCTSBPPP3CBABCC1ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226111-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-08-10 | — | — | US | disclosed |
| US-9623022-B2 | Macrocyclic inhibitors of hepatitis C virus | JANSSEN SCIENCES IRELAND UC (IE) | 2017-04-18 | — | — | US | disclosed |
| US-9040562-B2 | Macrocyclic inhibitors of hepatitis C virus | JANSSEN R&D IRELAND (IE) | 2015-05-26 | — | — | US | disclosed |
| US-20140255347-A1 | Macrocyclic Inhibitors Of Hepatitis C Virus | JANSSEN R&D IRELAND (IE) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226111-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS | CYP2A7, CYP3A7, HCCS | CTSS 1949/4885CTSB 3370/4885PPP3CB 2809/4885 |
| US-20140255347-A1 | Macrocyclic Inhibitors Of Hepatitis C Virus | CYP2A7, CYP3A7, HCCS | CTSS 1949/4885CTSB 3370/4885PPP3CB 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.