Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602231 | 0.87 | OPRD1 (0.69) | OPRD1OPRM1KCNH2OPRK1 | |
| SCHEMBL5444778 | 0.87 | OPRD1 (0.57) | OPRD1OPRM1KCNH2OPRK1 | |
| SCHEMBL17843396 | 0.86 | OPRD1 (0.49) | OPRD1OPRM1KCNH2LMNASMN1; SMN2 | |
| SCHEMBL5444769 | 0.86 | OPRD1 (0.70) | OPRD1OPRM1KCNH2LMNAHPGD | |
| SCHEMBL1603597 | 0.83 | OPRD1 (0.64) | OPRD1OPRM1KCNH2LMNAHPGD | |
| SCHEMBL4999897 | 0.83 | OPRD1 (0.71) | OPRD1OPRM1KCNH2HTTOPRK1 | |
| SCHEMBL5727386 | 0.82 | OPRD1 (0.68) | OPRD1OPRM1KCNH2OPRK1 | |
| SCHEMBL5943108 | 0.81 | OPRD1 (0.50) | OPRD1OPRM1KCNH2LMNAHPGD | |
| SCHEMBL5943105 | 0.81 | OPRD1 (0.50) | OPRD1OPRM1KCNH2LMNAHPGD | |
| SCHEMBL1603178 | 0.80 | OPRD1 (0.61) | OPRD1OPRM1KCNH2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082173-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2011-04-07 | — | — | US | disclosed |
| US-20070099957-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | ASTRA ZENECA AB (SE) | 2007-05-03 | — | — | US | disclosed |
| EP-1590346-B1 | 4- {'3-(SULFONYLAMINO) PHENYL] '1-(CYCLYMETHYL) PIPERIDIN-4-YLIDENE] METHYL} BENAZMIDE DERIVATIVES AS DELTA OPIOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN, ANXIETY AND FUNCTIONAL GASTROINTESTINAL DISORDER | ASTRAZENECA AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| US-20060154964-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | US | disclosed |
| EP-1590346-A1 | 4- {'3-(SULFONYLAMINO) PHENYL! '1-(CYCLYMETHYL) PIPERIDIN-4-YLIDENE! METHYL} BENAZMIDE DERIVATIVES AS DELTA OPIOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN, ANXIETY AND FUNCTIONAL GASTROINTESTINAL DISORDER | Astrazeneca AB (SE) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004063193-A1 | 4-{`3-(SULFONYLAMINO) PHENYL! `1-(CYCLYMETHYL) PIPERIDIN-4-YLIDENE! METHYL} BENAZMIDE DERIVATIVES AS DELTA OPIOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN, ANXIETY AND FUNCTIONAL GASTROINTESTINAL DISORDER | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154964-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | OPRM1, OPRD1, OPRL1 | OPRD1 2/4885OPRM1 1/4885KCNH2 113/4885 |
| US-20070099957-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | OPRM1, OPRD1, QDPR | OPRD1 2/4885OPRM1 1/4885KCNH2 72/4885 |
| US-20110082173-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | OPRM1, OPRD1, QDPR | OPRD1 2/4885OPRM1 1/4885KCNH2 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.