Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.57 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30861665 | 1.00 | SIRT2 (0.57) | SIRT2SIRT1SIRT5KDM4ELMNA | |
| SCHEMBL1616299 | 0.86 | KDM4E (0.58) | KDM4ELMNAKMT2AHPGDIGF1R | |
| SCHEMBL6420665 | 0.80 | KDM4E (0.46) | SIRT2SIRT1SIRT5KDM4ELMNA | |
| SCHEMBL31358694 | 0.79 | SIRT2 (0.67) | SIRT2SIRT1SIRT5KDM4ELMNA | |
| SCHEMBL6573721 | 0.75 | SIRT2 (0.81) | SIRT2SIRT1SIRT5KDM4ELMNA | |
| SCHEMBL6009639 | 0.73 | ALDH1A1 (0.47) | SIRT2SIRT1SIRT5KDM4ELMNA | |
| SCHEMBL31358825 | 0.72 | HPGD (0.60) | SIRT2SIRT1SIRT5KDM4ELMNA | |
| SCHEMBL31358679 | 0.72 | IGF1R (0.64) | SIRT2SIRT1SIRT5KDM4ELMNA | |
| SCHEMBL1728691 | 0.72 | MAPT (0.64) | KDM4ELMNAKMT2AHPGDIGF1R | |
| SCHEMBL4697667 | 0.72 | HPGD (0.65) | KDM4ELMNAKMT2AHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611868-A | Furanamide derivative and preparation method and application thereof | 山东大学 | 2023-01-17 | — | — | CN | claimed |
| WO-2024103400-A1 | POLYCYCLIC COMPOUND AS GPR75 ACTIVATOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | 水木未来(北京)科技有限公司 | 2024-05-23 | — | — | WO | disclosed |
| CN-117820303-A | Tetrahydroacridine-9 carboxylic acid derivative and preparation method and application thereof | 中国药科大学 | 2024-04-05 | — | — | CN | disclosed |
| CN-115611868-A | Furanamide derivative and preparation method and application thereof | 山东大学 | 2023-01-17 | — | — | CN | disclosed |
| EP-3226858-B1 | IMIDAZOLE-BASED ANTIMICROBIAL AGENTS | PROCOMCURE BIOTECH GMBH (AT) | 2021-02-03 | — | — | EP | disclosed |
| US-10456379-B2 | Imidazole-based antimicrobial agents | PROCOMCURE BIOTECH GMBH (AT) | 2019-10-29 | — | — | US | disclosed |
| US-10322110-B2 | Imidazole-based antimicrobial agents | PROCOMCURE BIOTECH GMBH (AT) | 2019-06-18 | — | — | US | disclosed |
| US-10011578-B2 | Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2018-07-03 | — | — | US | disclosed |
| US-20180022722-A1 | Compounds for Stabilizing Ryanodine Receptors from Aberrant Levels of Calcium Release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | 2018-01-25 | — | — | US | disclosed |
| US-20170368032-A1 | Imidazole-Based Antimicrobial Agents | PROCOMCURE BIOTECH GMBH (AT) | 2017-12-28 | — | — | US | disclosed |
| US-20170334887-A1 | Imidazole-Based Antimicrobial Agents | PROCOMCURE BIOTECH GMBH (AT) | 2017-11-23 | — | — | US | disclosed |
| EP-3226858-A1 | IMIDAZOLE-BASED ANTIMICROBIAL AGENTS | Procomcure Biotech GmbH (AT) | 2017-10-11 | — | — | EP | disclosed |
| US-9725429-B2 | Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2017-08-08 | — | — | US | disclosed |
| WO-2016087616-A1 | IMIDAZOLE-BASED ANTIMICROBIAL AGENTS | PROCOMCURE BIOTECH GMBH (AT) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016087618-A1 | IMIDAZOLE-BASED ANTIMICROBIAL AGENTS | PROCOMCURE BIOTECH GMBH (AT) | 2016-06-09 | — | — | WO | disclosed |
| US-20160024038-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | 2016-01-28 | — | — | US | disclosed |
| EP-2968229-A1 | COMPOUNDS FOR STABILIZING RYANODINE RECEPTORS FROM ABERRANT LEVELS OF CALCIUM RELEASE | Rosalind Franklin University of Medicine and Science (US) | 2016-01-20 | — | — | EP | disclosed |
| US-9102645-B2 | Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2015-08-11 | — | — | US | disclosed |
| WO-2014144654-A1 | COMPOUNDS FOR STABILIZING RYANODINE RECEPTORS FROM ABERRANT LEVELS OF CALCIUM RELEASE | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140275112-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022722-A1 | Compounds for Stabilizing Ryanodine Receptors from Aberrant Levels of Calcium Release | CHERP, RYR1, RYR2 | SIRT2 1409/4885SIRT1 555/4885SIRT5 2283/4885 |
| US-20170334887-A1 | Imidazole-Based Antimicrobial Agents | TLR5, NISCH, SLC11A2 | SIRT2 1043/4885SIRT1 802/4885SIRT5 156/4885 |
| US-20140275112-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | CHERP, RYR1, RYR2 | SIRT2 1409/4885SIRT1 555/4885SIRT5 2283/4885 |
| US-10456379-B2 | Imidazole-based antimicrobial agents | TLR5, NISCH, SLC11A2 | SIRT2 1043/4885SIRT1 802/4885SIRT5 156/4885 |
| US-10322110-B2 | Imidazole-based antimicrobial agents | ARG1, SLC11A2, IKZF3 | SIRT2 1171/4885SIRT1 1602/4885SIRT5 486/4885 |
| US-10011578-B2 | Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | CHERP, RYR1, RYR2 | SIRT2 1409/4885SIRT1 555/4885SIRT5 2283/4885 |
| US-20170368032-A1 | Imidazole-Based Antimicrobial Agents | TLR5, NISCH, SLC11A2 | SIRT2 1043/4885SIRT1 802/4885SIRT5 156/4885 |
| US-20160024038-A1 | Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release | CHERP, RYR1, RYR2 | SIRT2 1409/4885SIRT1 555/4885SIRT5 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.