Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 16/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.58 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1603206 | 0.93 | OPRD1 (0.64) | OPRD1OPRM1OPRK1KCNA5KCNH2 | |
| SCHEMBL1604051 | 0.84 | OPRD1 (0.70) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL1603368 | 0.82 | OPRD1 (0.62) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL1603013 | 0.82 | OPRD1 (0.61) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL1603243 | 0.81 | OPRD1 (0.63) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL1603960 | 0.81 | OPRD1 (0.68) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL1603412 | 0.80 | OPRD1 (0.69) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL1603316 | 0.79 | OPRD1 (0.69) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL5391009 | 0.79 | OPRD1 (0.80) | OPRD1OPRM1OPRK1KCNH2ABCB11 | |
| SCHEMBL1602876 | 0.79 | OPRD1 (0.70) | OPRD1OPRM1OPRK1KCNH2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082173-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2011-04-07 | — | — | US | claimed |
| US-20070099957-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | ASTRA ZENECA AB (SE) | 2007-05-03 | — | — | US | claimed |
| US-20110082173-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2011-04-07 | — | — | US | disclosed |
| US-20110082173-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2011-04-07 | — | — | US | disclosed |
| US-20110082173-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2011-04-07 | — | — | US | disclosed |
| US-20070099957-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | ASTRA ZENECA AB (SE) | 2007-05-03 | — | — | US | disclosed |
| US-20070099957-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | ASTRA ZENECA AB (SE) | 2007-05-03 | — | — | US | disclosed |
| US-20070099957-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | ASTRA ZENECA AB (SE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099957-A1 | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof | OPRM1, OPRD1, QDPR | OPRD1 2/4885OPRM1 1/4885OPRK1 7/4885 |
| US-20110082173-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | OPRM1, OPRD1, QDPR | OPRD1 2/4885OPRM1 1/4885OPRK1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.