SCHEMBL160357

SCHEMBL160357

CS[C@@]1(n2cnc3c(N)ncnc32)O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 5/20 0.53
ADORA2A P29274 3/20 0.53
PI4KA P42356 2/20 0.50
PI4K2B Q8TCG2 2/20 0.50
PI4K2A Q9BTU6 2/20 0.50
PI4KB Q9UBF8 2/20 0.50
SLC28A1 O00337 2/20 0.50
ADORA2B P29275 2/20 0.50
ADORA1 P30542 2/20 0.50
DPP4 P27487 1/20 0.50
MEN1 O00255 1/20 0.50
MAP3K7 O43318 1/20 0.50
SLC28A2 O43868 1/20 0.50
GAPDH P04406 1/20 0.50
MAPK1 P28482 1/20 0.50
STAT6 P42226 1/20 0.50
KMT2A Q03164 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
DOT1L Q8TEK3 1/20 0.50
SLC29A1 Q99808 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL998090 0.89 PI4KA (0.48) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL6935380 0.88 PI4KA (0.48) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL2228473 0.88 PI4KA (0.39) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL5742060 0.87 PI4KA (0.47) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL9495963 0.86 PI4KA (0.46) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL3488876 0.86 ADORA3 (0.47) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL4884759 0.86 EHMT1 (0.48) ADORA3ADORA2API4KAPI4K2BPI4K2A
Niacinamide SCHEMBL8447045 0.85 EGFR (0.47) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL934614 0.85 ADORA3 (0.47) ADORA3ADORA2API4KAPI4K2BPI4K2A
SCHEMBL7200116 0.85 ADORA3 (0.53) ADORA3ADORA2API4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1624 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
WO-2026107412-A1 SARCOSPAN MODULATION AND METHODS OF MEAT AND TISSUE CULTURE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-05-21 WO claimed
WO-2025217007-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-16 WO claimed
WO-2025217015-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-16 WO claimed
WO-2025217008-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-16 WO claimed
US-20250312344-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-09 US claimed
US-20250312351-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-09 US claimed
US-20250312343-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-10-09 US claimed
EP-4580628-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND BCL-2 FAMILY INHIBITORS FOR THE TREATMENT OF CANCER Mirati Therapeutics, Inc. (US) 2025-07-09 EP claimed
US-12331343-B2 FAMIN assay methods CAMBRIDGE ENTERPRISE LIMITED (GB) 2025-06-17 US claimed
EP-0675712-A4 REDUCTION OF HAIR GROWTH EMPLOYING SULFHYDRYL REACTIVE COMPOUNDS. HANDELMAN JOSEPH H (US) 1996-11-06 EP claimed
WO-1996033703-A2 S-ADENOSYL METHIONINE REGULATION OF METABOLIC PATHWAYS AND ITS USE IN DIAGNOSIS AND THERAPY ORIDIGM CORPORATION (US) 1996-10-31 WO claimed
CN-1121356-A Use of tomato E8-derived promoters to express heterologous genes, E.G. 5-adenosylmethionine hydrolase, in ripening fruit EPITOPE INC (US) 1996-04-24 CN claimed
WO-1996010402-A1 MULTI-FACETED METHOD TO REPRESS REPRODUCTION OF LATENT VIRUSES IN HUMANS AND ANIMALS DYKE KNOX VAN (US) 1996-04-11 WO claimed
EP-0675712-A1 REDUCTION OF HAIR GROWTH EMPLOYING SULFHYDRYL REACTIVE COMPOUNDS HANDELMAN, Joseph H. (US) 1995-10-11 EP claimed
EP-0555352-A4 AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES HEALTH RESEARCH INC (US) 1994-12-14 EP claimed
WO-1994014428-A1 REDUCTION OF HAIR GROWTH EMPLOYING SULFHYDRYL REACTIVE COMPOUNDS HANDELMAN, JOSEPH, H. (US) 1994-07-07 WO claimed
US-4948783-A ORALLY ADMINISTERING ADENOSINE OR DERIVATIVE KABUSHIKI KAISYA ADVANCE KAIHATSU KENKYUJO (JP) 1990-08-14 US claimed
US-4562149-A CULTIVATING A MICROORGANISM IN LIQUID CULTURE MEDIUM CONTAINING METHIONINE NIPPON ZEON CO., LTD. (JP) 1985-12-31 US claimed
US-3962034-A CULTURE AJINOMOTO CO., INC. (JA) 1976-06-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250312351-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND SOS1 INHIBITORS FOR THE TREATMENT OF CANCER PRMT1, PRMT5, PRMT6 ADORA3 3358/4885ADORA2A 2256/4885PI4KA 2564/4885
US-20250312343-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER KRAS, PRMT5, NRAS ADORA3 2918/4885ADORA2A 1842/4885PI4KA 1262/4885
US-20250312344-A1 COMBINATION THERAPIES USING PRMT5 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF CANCER PRMT5, PRMT1, PRMT6 ADORA3 1844/4885ADORA2A 955/4885PI4KA 1720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.