SCHEMBL16035705

SCHEMBL16035705

CCc1cccnc1-n1nnc2c1CCN(C(=O)c1cccc(C(F)(F)F)c1)C2C

nearest known ligand 0.69

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 20/20 0.69
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16089676 0.88 P2RX7 (0.63) P2RX7
SCHEMBL16036981 0.82 P2RX7 (0.67) P2RX7
SCHEMBL18880771 0.75 GRIN2C (0.40) P2RX7CYP2C9
SCHEMBL20184288 0.72 P2RX7 (0.54) P2RX7
SCHEMBL16036108 0.72 P2RX7 (1.00) P2RX7CYP2C9CYP2C19
SCHEMBL16036348 0.72 P2RX7 (1.00) P2RX7CYP2C9CYP2C19
SCHEMBL16036857 0.71 P2RX7 (1.00) P2RX7CYP2C9CYP2C19
SCHEMBL16035754 0.71 P2RX7 (1.00) P2RX7CYP2C9CYP2C19
SCHEMBL16035822 0.70 P2RX7 (1.00) P2RX7CYP2C9CYP2C19
SCHEMBL16035383 0.70 P2RX7 (1.00) P2RX7CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 US claimed
EP-3495365-A1 P2X7 MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP claimed
US-10112937-B2 P2X7 modulators and methods of use JANSSEN PHARMACEUTICA NV (BE) 2018-10-30 US claimed
EP-2970267-B3 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-05-30 EP claimed
EP-2970267-B1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2017-05-24 EP claimed
US-20160376271-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV 2016-12-29 US claimed
US-20160039809-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2016-02-11 US claimed
EP-2970267-A1 P2X7 MODULATORS Janssen Pharmaceutica, N.V. (BE) 2016-01-20 EP claimed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US claimed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO claimed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US claimed
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO disclosed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C9 913/4885CYP2C19 704/4885
US-20160376271-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C9 913/4885CYP2C19 704/4885
US-10112937-B2 P2X7 modulators and methods of use P2RX2, P2RX7, P2RX5 P2RX7 2/4885CYP2C9 638/4885CYP2C19 530/4885
US-20160039809-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RX5 P2RX7 2/4885CYP2C9 680/4885CYP2C19 587/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C9 913/4885CYP2C19 704/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C9 913/4885CYP2C19 704/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C9 913/4885CYP2C19 704/4885
US-20140275015-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C9 913/4885CYP2C19 704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.