SCHEMBL16036331

SCHEMBL16036331

C[C@H]1c2nc[nH]c2CCN1Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.43
AOC3 Q16853 2/20 0.42
CYP2C19 P33261 1/20 0.38
ACHE P22303 1/20 0.38
MAPT P10636 1/20 0.37
ACP1 P24666 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
DRD2 P14416 1/20 0.36
DRD4 P21917 1/20 0.36
DRD3 P35462 1/20 0.36
TMEM97 Q5BJF2 1/20 0.36
RECQL P46063 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16035902 1.00 RAB9A (0.43) RAB9AAOC3CYP2C19ACHEMAPT
SCHEMBL16036328 1.00 RAB9A (0.43) RAB9AAOC3CYP2C19ACHEMAPT
SCHEMBL24062104 0.83 RAB9A (0.48) RAB9AAOC3CYP2C19MAPTACP1
SCHEMBL2797262 0.82 MAPT (0.46) CYP2C19MAPT
SCHEMBL18880432 0.78 CYP2C19 (0.36) CYP2C19ACHEMAPTACP1SIGMAR1
SCHEMBL18408202 0.74 ADRA1A (0.39) CYP2C19SIGMAR1DRD2DRD4DRD3
SCHEMBL28957987 0.74 GAA (0.41) CYP2C19MAPT
SCHEMBL31595883 0.74 HTR2B (0.44) RAB9AMAPTDRD2DRD4DRD3
SCHEMBL31595955 0.74 MEN1 (0.41) RAB9ACYP2C19MAPTDRD2DRD4
SCHEMBL16035432 0.72 KMT2A (0.39) CYP2C19ACHEMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 US disclosed
US-20200325138-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2020-10-15 US disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200325138-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885
US-11225478-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885
US-20150322062-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885
US-20140275015-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RAB9A 3242/4885AOC3 3229/4885CYP2C19 704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.