Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.79 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.66 |
| ▸ | NQO2 | P16083 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SNCA | P37840 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11688443 | 0.94 | DEGS1 (0.83) | DEGS1PTPN1POLBKDM4ENPC1 | |
| N-Phenylbenzamide SCHEMBL27671345 | 0.92 | POLB (0.71) | DEGS1PTPN1POLBKDM4EHDAC2 | |
| SCHEMBL679222 | 0.92 | DEGS1 (0.79) | DEGS1PTPN1POLBKDM4ENPC1 | |
| SCHEMBL1315526 | 0.91 | PTPN1 (0.87) | PTPN1POLBKDM4EHDAC2HDAC8 | |
| SCHEMBL14715847 | 0.89 | PTPN1 (0.84) | DEGS1PTPN1POLBKDM4EHDAC2 | |
| SCHEMBL8420639 | 0.89 | DEGS1 (0.75) | DEGS1PTPN1POLBKDM4ENPC1 | |
| SCHEMBL900928 | 0.89 | DEGS1 (0.75) | DEGS1PTPN1POLBKDM4ENPC1 | |
| SCHEMBL899585 | 0.89 | DEGS1 (0.75) | DEGS1PTPN1POLBKDM4ENPC1 | |
| SCHEMBL11877527 | 0.89 | DEGS1 (1.00) | DEGS1PTPN1POLBKDM4ENPC1 | |
| SCHEMBL26953087 | 0.87 | PTPN1 (0.88) | PTPN1POLBKDM4EHDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112778154-B | Aryl alkyl ether compound and derivative thereof, preparation method, pharmaceutical composition and application | 中国药科大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-112778154-A | Aryl alkyl ether compound and derivative thereof, preparation method, pharmaceutical composition and application | 中国药科大学 | 2021-05-11 | — | — | CN | disclosed |
| US-20200087248-A1 | Fluoroallylamine Derivative And Use Thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2020-03-19 | — | — | US | disclosed |
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2019-06-25 | — | — | US | disclosed |
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |
| US-20160264548-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-09-15 | — | — | US | disclosed |
| CN-105939998-A | Heteroaryl compounds as btk inhibitors and uses thereof | 默克专利有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-3060550-A2 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | Merck Patent GmbH (DE) | 2016-08-31 | — | — | EP | disclosed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |
| WO-2015061247-A2 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2015-04-30 | — | — | WO | disclosed |
| EP-0409069-A2 | Mesogenic polycyanates and thermosets thereof | THE DOW CHEMICAL COMPANY (US) | 1991-01-23 | — | — | EP | disclosed |
| EP-0379057-A2 | Mesogenic epoxy compounds | THE DOW CHEMICAL COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
| EP-0113778-B1 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-09 | — | — | EP | disclosed |
| US-4923873-A | ANTIARRHYTHMIA AGENTS; SIDE EFFECT REDUCTION | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-08 | — | — | US | disclosed |
| US-4755527-A | Aryl substituted aminomethyl benzene derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-07-05 | — | — | US | disclosed |
| US-4748184-A | Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| US-4562201-A | ANTIARRHYTHMIA AGNETS | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-12-31 | — | — | US | disclosed |
| EP-0113778-A4 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1985-06-06 | — | — | EP | disclosed |
| EP-0113778-A1 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS. | AMERICAN HOSPITAL SUPPLY CORP (US) | 1984-07-25 | — | — | EP | disclosed |
| WO-1984000545-A1 | ARYL SUBSTITUTED AMINOMETHYL BENZENE DERIVATIVES USEFUL AS ANTIARRHYTHMIC AGENTS | AMERICAN HOSPITAL SUPPLY CORP (US) | 1984-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264548-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | BTK, SYK, LCK | DEGS1 4489/4885PTPN1 61/4885POLB 3356/4885 |
| US-20200087248-A1 | Fluoroallylamine Derivative And Use Thereof | VAPB, VAPA, SLC28A1 | DEGS1 1203/4885PTPN1 2876/4885POLB 1289/4885 |
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | BTK, SYK, LCK | DEGS1 4489/4885PTPN1 61/4885POLB 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.