Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018019 | 0.82 | PIK3CD (0.45) | BACE1BACE2CYP3A4PIK3CDPIK3CA | |
| SCHEMBL12629375 | 0.80 | TRPA1 (0.44) | CYP11B1CYP11B2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL2038092 | 0.74 | PTGS2 (0.37) | PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2043009 | 0.72 | ATM (0.44) | PIK3CDPIK3R1PIK3CBPIK3CGDPP4 | |
| SCHEMBL12197126 | 0.71 | PIK3CD (0.60) | CYP11B1CYP11B2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL2504442 | 0.70 | PIK3CD (0.55) | CYP11B1CYP11B2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL16039095 | 0.70 | TRPM8 (0.47) | PDE4BTP53TRPA1KDM4C | |
| SCHEMBL2034647 | 0.70 | NR1H3 (0.53) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2553878 | 0.69 | PIK3CD (0.58) | CYP11B1CYP11B2PIK3CDPIK3R1PIK3CB | |
| SCHEMBL2507030 | 0.69 | PIK3CD (0.58) | CYP11B1CYP11B2PIK3CDPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275127-A1 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275127-A1 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS | PIK3CA, PIK3CD, PIK3R5 | PDE4B 1686/4885TP53 680/4885CTSD 3316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.