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Sugi Predict / Compounds / (Z)-1,2-Diphenylethene

(Z)-1,2-Diphenylethene

(Z)-1,2-Diphenylethene

SCHEMBL1604067

C(=Cc1ccccc1)c1ccccc1.COC(=O)c1ccccc1

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.76
▸ CA1 P00915 1/20 0.60
▸ CA2 P00918 1/20 0.60
▸ PTPN1 P18031 2/20 0.57
▸ RAB9A P51151 8/20 0.55
▸ NPC1 O15118 6/20 0.55
▸ CYP1A2 P05177 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ HSD17B10 Q99714 1/20 0.55
▸ POLB P06746 1/20 0.55
▸ ALDH1A1 P00352 2/20 0.55
▸ MAPT P10636 4/20 0.55
▸ CASP3 P42574 1/20 0.55
▸ SENP8 Q96LD8 1/20 0.55
▸ SENP7 Q9BQF6 1/20 0.55
▸ SENP6 Q9GZR1 1/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.55
▸ LMNA P02545 2/20 0.54
▸ HDAC1 Q13547 1/20 0.53
▸ PLA2G7 Q13093 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(Z)-1,2-Diphenylethene SCHEMBL1604066 1.00 TSHR (0.76) TSHRCA1CA2PTPN1RAB9A
SCHEMBL521421 0.94 TSHR (0.67) TSHRCA1CA2PTPN1RAB9A
SCHEMBL521422 0.94 TSHR (0.67) TSHRCA1CA2PTPN1RAB9A
SCHEMBL29496462 0.89 P4HB (0.62) TSHRPTPN1RAB9ANPC1CYP1A2
SCHEMBL1926761 0.89 P4HB (0.62) TSHRPTPN1RAB9ANPC1CYP1A2
SCHEMBL24411012 0.89 P4HB (0.62) TSHRPTPN1RAB9ANPC1CYP1A2
SCHEMBL1926762 0.89 P4HB (0.62) TSHRPTPN1RAB9ANPC1CYP1A2
Methyl Benzoate SCHEMBL29831725 0.87 TSHR (1.00) TSHRCA1CA2PTPN1RAB9A
Methyl Benzoate SCHEMBL1867855 0.87 TSHR (1.00) TSHRCA1CA2PTPN1RAB9A
Methyl Benzoate SCHEMBL7200 0.87 TSHR (1.00) TSHRCA1CA2PTPN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8242144-B2 Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases RESVERLOGIX CORP. (CA) 2012-08-14 — — US disclosed
US-20110082176-A1 Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases RESVERLOGIX CORP. 2011-04-07 — — US disclosed
US-7846915-B2 Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases Resverlogix Corporation (CA) 2010-12-07 — — US disclosed
US-20060205792-A1 Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases HEPALINK (HONG KONG) LIMITED (HK) 2006-09-14 — — US disclosed
WO-2006045010-A2 STILBENES AND CHALCONES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES RESVERLOGIX CORP. (CA) 2006-04-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060205792-A1 Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases APOB, APOL1, HDLBP TSHR 4462/4885CA1 4876/4885CA2 4874/4885
US-20110082176-A1 Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases APOB, APOL1, HDLBP TSHR 4462/4885CA1 4876/4885CA2 4874/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.