Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23219219 | 0.83 | MEN1 (0.58) | MEN1KMT2AALOX5PTGS2LMNA | |
| SCHEMBL31748615 | 0.79 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL27958054 | 0.78 | MEN1 (0.83) | MEN1KMT2AALOX5PTGS2LMNA | |
| SCHEMBL31748775 | 0.77 | PDE4A (0.43) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31748671 | 0.76 | LMNA (0.41) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL4390782 | 0.76 | PDE4A (0.57) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL16053261 | 0.76 | PRKAG1 (0.49) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL5427469 | 0.74 | MEN1 (0.49) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL20141417 | 0.73 | MEN1 (0.48) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL22748352 | 0.73 | CA1 (0.47) | MEN1KMT2AALOX5LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394285-B2 | Indole and indazole compounds that activate AMPK | PFIZER INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394285-B2 | Indole and indazole compounds that activate AMPK | PFIZER INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394285-B2 | Indole and indazole compounds that activate AMPK | PFIZER INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PFIZER, INC. (US) | 2016-01-21 | — | — | US | disclosed |
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PFIZER, INC. (US) | 2016-01-21 | — | — | US | disclosed |
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PFIZER, INC. (US) | 2016-01-21 | — | — | US | disclosed |
| EP-2970177-A1 | INDOLE COMPOUNDS THAT ACTIVATE AMPK | Pfizer Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014140704-A1 | INDOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014140704-A1 | INDOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PRKAG1, PRKAG3, PRKAG2 | MEN1 4037/4885KMT2A 1740/4885PDE4A 229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.