Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16058180 | 0.81 | PGK1 (0.33) | TYRNPC1RAB9APDE4AADORA2A | |
| SCHEMBL16058181 | 0.69 | TYMP (0.42) | TYR | |
| SCHEMBL16058031 | 0.61 | TYMP (0.32) | NPC1RAB9A | |
| SCHEMBL18686733 | 0.57 | TYR (0.41) | TYRPDE4AADORA2AADORA2BPDE4B | |
| SCHEMBL4150749 | 0.56 | PDE4A (0.42) | PDE4AADORA2AADORA2BPDE4BPDE4C | |
| SCHEMBL11769027 | 0.55 | PDE4A (0.37) | TYRPDE4AADORA2AADORA2BPDE4B | |
| SCHEMBL23214051 | 0.53 | ALDH1A1 (0.37) | TYRNPC1RAB9A | |
| SCHEMBL15906247 | 0.52 | TYR (0.37) | TYRPDE4AADORA2AADORA2BPDE4B | |
| SCHEMBL10044418 | 0.52 | PDE4A (0.39) | TYRPDE4AADORA2AADORA2BPDE4B | |
| SCHEMBL19405809 | 0.51 | TYR (0.44) | TYRADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10449207-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180360859-A1 | Acyclic Nucleoside Phosphonate Diesters | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-12-20 | — | — | US | disclosed |
| US-10076532-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-18 | — | — | US | disclosed |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-10-26 | — | — | US | disclosed |
| US-9775852-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-03 | — | — | US | disclosed |
| US-20170002033-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-05 | — | — | US | disclosed |
| US-9387217-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-07-12 | — | — | US | disclosed |
| US-20160015726-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-01-21 | — | — | US | disclosed |
| EP-2970346-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | The Regents of the University of California (US) | 2016-01-20 | — | — | EP | disclosed |
| US-9156867-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-10-13 | — | — | US | disclosed |
| US-20140364397-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION | 2014-12-11 | — | — | US | disclosed |
| WO-2014143643-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160015726-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYR 4401/4885NPC1 349/4885RAB9A 1901/4885 |
| US-20180360859-A1 | Acyclic Nucleoside Phosphonate Diesters | NTPCR, PNP, TYMP | TYR 4401/4885NPC1 349/4885RAB9A 1901/4885 |
| US-20170002033-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYR 4401/4885NPC1 349/4885RAB9A 1901/4885 |
| US-10449207-B2 | Acyclic nucleoside phosphonate diesters | NTPCR, PNP, TYMP | TYR 4401/4885NPC1 349/4885RAB9A 1901/4885 |
| US-10076532-B2 | Acyclic nucleoside phosphonate diesters | NTPCR, PNP, TYMP | TYR 4401/4885NPC1 349/4885RAB9A 1901/4885 |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYR 4401/4885NPC1 349/4885RAB9A 1901/4885 |
| US-20140364397-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYR 4401/4885NPC1 349/4885RAB9A 1901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.