Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 4/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16058031 | 0.76 | TYMP (0.32) | TYMP | |
| SCHEMBL16058178 | 0.75 | KDM4E (0.37) | TYMPALDH1A1 | |
| SCHEMBL16058180 | 0.70 | PGK1 (0.33) | TYRALDH1A1 | |
| SCHEMBL8708528 | 0.65 | TYMP (0.32) | TYMP | |
| SCHEMBL26124117 | 0.64 | BRD4 (0.36) | ALDH1A1 | |
| SCHEMBL16037869 | 0.63 | TYMP (0.52) | TYMP | |
| SCHEMBL25980045 | 0.62 | LMNA (0.46) | ALDH1A1 | |
| SCHEMBL16058029 | 0.62 | — | — | |
| SCHEMBL16056937 | 0.59 | FGFR1 (0.37) | TYMP | |
| SCHEMBL3854773 | 0.59 | TYMP (1.00) | TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10449207-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180360859-A1 | Acyclic Nucleoside Phosphonate Diesters | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-12-20 | — | — | US | disclosed |
| US-10076532-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-18 | — | — | US | disclosed |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-10-26 | — | — | US | disclosed |
| US-9775852-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-03 | — | — | US | disclosed |
| US-20170002033-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-05 | — | — | US | disclosed |
| US-9387217-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-07-12 | — | — | US | disclosed |
| US-20160015726-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-01-21 | — | — | US | disclosed |
| EP-2970346-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | The Regents of the University of California (US) | 2016-01-20 | — | — | EP | disclosed |
| US-9156867-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-10-13 | — | — | US | disclosed |
| US-20140364397-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION | 2014-12-11 | — | — | US | disclosed |
| WO-2014143643-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160015726-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYMP 3/4885TYR 4401/4885ALDH1A1 2502/4885 |
| US-20180360859-A1 | Acyclic Nucleoside Phosphonate Diesters | NTPCR, PNP, TYMP | TYMP 3/4885TYR 4401/4885ALDH1A1 2502/4885 |
| US-20170002033-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYMP 3/4885TYR 4401/4885ALDH1A1 2502/4885 |
| US-10449207-B2 | Acyclic nucleoside phosphonate diesters | NTPCR, PNP, TYMP | TYMP 3/4885TYR 4401/4885ALDH1A1 2502/4885 |
| US-10076532-B2 | Acyclic nucleoside phosphonate diesters | NTPCR, PNP, TYMP | TYMP 3/4885TYR 4401/4885ALDH1A1 2502/4885 |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYMP 3/4885TYR 4401/4885ALDH1A1 2502/4885 |
| US-20140364397-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | TYMP 3/4885TYR 4401/4885ALDH1A1 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.