Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17100482 | 0.70 | SMN1; SMN2 (0.41) | BLMCYP2D6CHRM2LMNAALDH1A1 | |
| SCHEMBL9459628 | 0.70 | L3MBTL1 (0.43) | BLMCYP2D6CHRM2LMNAALDH1A1 | |
| SCHEMBL13269728 | 0.68 | L3MBTL1 (0.44) | BLMCYP2D6LMNAALDH1A1PMP22 | |
| SCHEMBL28996741 | 0.68 | BLM (0.42) | BLMCYP2D6CHRM2LMNAALDH1A1 | |
| SCHEMBL7828236 | 0.67 | L3MBTL1 (0.47) | BLMCYP2D6LMNAALDH1A1KDM4E | |
| Hydrogen Sulfide SCHEMBL30335073 | 0.67 | BLM (0.41) | BLMCYP2D6CHRM2LMNAALDH1A1 | |
| SCHEMBL25500507 | 0.66 | L3MBTL1 (0.46) | BLMCYP2D6CHRM2LMNAALDH1A1 | |
| SCHEMBL3743980 | 0.66 | L3MBTL1 (0.46) | BLMCYP2D6LMNAALDH1A1PMP22 | |
| SCHEMBL11206142 | 0.66 | TSHR (0.39) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4728011 | 0.64 | SMN1; SMN2 (0.50) | BLMCYP2D6CHRM2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044650-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
| EP-2970266-A1 | 1 -PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144455-A1 | 1 -PHENOXY-3-(ALKYLAMINO)-PROPAN-2-OL DERIVATIVES AS CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |