Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27566686 | 0.81 | — | — | |
| SCHEMBL13702951 | 0.75 | PDE10A (0.37) | SPNS2MAPTLMNAALDH1A1PDE10A | |
| SCHEMBL15033451 | 0.73 | PDE10A (0.35) | SPNS2MAPTLMNATSHRALDH1A1 | |
| SCHEMBL21564316 | 0.72 | HCAR2 (0.41) | MAPTLMNATSHRALDH1A1KDM4E | |
| SCHEMBL28185774 | 0.71 | PDE10A (0.40) | ALDH1A1PDE10A | |
| SCHEMBL27306641 | 0.69 | CTSK (0.36) | SPNS2MAPTLMNAALDH1A1PDE10A | |
| SCHEMBL21564318 | 0.68 | PDE10A (0.38) | MAPTPDE10AMEN1KMT2A | |
| SCHEMBL13384289 | 0.68 | NOS3 (0.33) | SPNS2MAPTLMNAKDM4EMEN1 | |
| SCHEMBL12362482 | 0.67 | PDE10A (0.58) | PDE10A | |
| Bromide SCHEMBL21404082 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970142-A2 | FUNCTIONALIZED IONIC LIQUIDS AND THEIR APPLICATIONS | Materials Modification Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144523-A2 | FUNCTIONALIZED IONIC LIQUIDS AND THEIR APPLACATIONS | MATERIALS MODIFICATION INC. (US) | 2014-09-18 | — | — | WO | disclosed |