Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | POLA1 | P09884 | 1/20 | 0.54 |
| ▸ | POLG | P54098 | 1/20 | 0.54 |
| ▸ | HPRT1 | P00492 | 13/20 | 0.50 |
| ▸ | PNP | P00491 | 6/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16063286 | 0.91 | POLB (0.65) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL16063240 | 0.82 | POLB (0.62) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL2734888 | 0.79 | POLB (0.73) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL2734697 | 0.78 | POLB (0.77) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL16062930 | 0.76 | POLB (0.46) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL8717128 | 0.76 | POLB (0.68) | POLBPOLA1POLGHPRT1PNP | |
| Gs-438 SCHEMBL64567 | 0.75 | POLB (0.80) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL16062917 | 0.75 | POLB (0.64) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL17617347 | 0.74 | POLB (0.60) | POLBPOLA1POLGHPRT1PNP | |
| SCHEMBL8717524 | 0.74 | POLB (0.81) | POLBPOLA1POLGHPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071323-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-03-15 | — | — | US | disclosed |
| US-20180064737-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | UNIV CALIFORNIA (US) | 2018-03-08 | — | — | US | disclosed |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-10-26 | — | — | US | disclosed |
| US-9775852-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-03 | — | — | US | disclosed |
| US-20170189430-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-07-06 | — | — | US | disclosed |
| US-9629860-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-04-25 | — | — | US | disclosed |
| US-20170002033-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-05 | — | — | US | disclosed |
| US-9387217-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-07-12 | — | — | US | disclosed |
| US-20160015726-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-01-21 | — | — | US | disclosed |
| US-9156867-B2 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-10-13 | — | — | US | disclosed |
| US-20140364397-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION | 2014-12-11 | — | — | US | disclosed |
| US-20140275532-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140274959-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) | 2014-09-18 | — | — | US | disclosed |
| US-8835630-B1 | Acyclic nucleoside phosphonate diesters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION (US) | 2014-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180064737-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20170189430-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20140274959-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20160015726-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20170002033-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20140275532-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20170304330-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20180071323-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
| US-20140364397-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS | NTPCR, PNP, TYMP | POLB 147/4885POLA1 169/4885POLG 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.