Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | RORB | Q92753 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133453 | 0.87 | PTPN5 (0.69) | PTPN5SMN1; SMN2NPSR1KDM4EALDH1A1 | |
| SCHEMBL16673937 | 0.83 | CYP1A1 (0.53) | SMN1; SMN2NPSR1RAB9AKDM4EGAA | |
| SCHEMBL11434713 | 0.83 | PTPN5 (0.46) | PTPN5SMN1; SMN2NPSR1RAB9AKDM4E | |
| SCHEMBL22009314 | 0.81 | PTPN5 (0.54) | PTPN5SMN1; SMN2NPSR1KDM4EALDH1A1 | |
| SCHEMBL5735560 | 0.80 | CA1 (0.45) | PTPN5SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL16067895 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2NPSR1RAB9AKDM4EALDH1A1 | |
| SCHEMBL28761566 | 0.77 | PTPN5 (0.48) | PTPN5SMN1; SMN2RAB9AKDM4EGAA | |
| SCHEMBL3786711 | 0.77 | RORB (0.50) | PTPN5SMN1; SMN2NPSR1KDM4EALDH1A1 | |
| SCHEMBL5843347 | 0.76 | RORB (0.50) | PTPN5SMN1; SMN2NPSR1KDM4EALDH1A1 | |
| SCHEMBL357250 | 0.76 | NFE2L2 (0.49) | SMN1; SMN2RAB9AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014142273-A1 | DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE | 中外製薬株式会社 (JP) | 2014-09-18 | — | — | WO | disclosed |