Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21775849 | 0.81 | MEN1 (0.47) | ALDH1A1KDM4EHPGDGAANPC1 | |
| SCHEMBL21775854 | 0.81 | ALPL (0.44) | GAANPC1RAB9AALPLMAPT | |
| SCHEMBL5236193 | 0.79 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDGAANPC1 | |
| SCHEMBL19926235 | 0.79 | MAP4K1 (0.50) | ALDH1A1KDM4EHPGDGAANPC1 | |
| SCHEMBL29875448 | 0.79 | MAP4K1 (0.50) | ALDH1A1KDM4EHPGDGAANPC1 | |
| SCHEMBL21775713 | 0.78 | MKNK1 (0.46) | KDM4ENPC1RAB9AKDRMAP2K4 | |
| SCHEMBL19926065 | 0.78 | GSK3A (0.57) | ALDH1A1KDM4EHPGDGAANPC1 | |
| SCHEMBL4005629 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDGAANPC1 | |
| SCHEMBL4057416 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDGAANPC1 | |
| SCHEMBL13715982 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250230168-A1 | AZASPIRO WRN INHIBITORS | GILEAD SCIENCES, INC. | 2025-07-17 | — | — | US | disclosed |
| WO-2025137640-A1 | AZASPIRO WRN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| EP-2970141-B1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON CORP (US) | 2020-02-26 | — | — | EP | disclosed |
| US-20180186751-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2018-07-05 | — | — | US | disclosed |
| US-20180186751-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2018-07-05 | — | — | US | disclosed |
| US-20180186751-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2018-07-05 | — | — | US | disclosed |
| US-9951025-B2 | Halogenopyrazoles as inhibitors of thrombin | VERSEON CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951025-B2 | Halogenopyrazoles as inhibitors of thrombin | VERSEON CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951025-B2 | Halogenopyrazoles as inhibitors of thrombin | VERSEON CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160046585-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-02-18 | — | — | US | disclosed |
| US-20160046585-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-02-18 | — | — | US | disclosed |
| US-20160046585-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON INTERNATIONAL CORPORATION | 2016-02-18 | — | — | US | disclosed |
| WO-2014149139-A2 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014146059-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | VERSEON, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250230168-A1 | AZASPIRO WRN INHIBITORS | WRN, RECQL, BLM | ALDH1A1 1316/4885KDM4E 3650/4885HPGD 583/4885 |
| US-20180186751-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | F2, TFPI, SERPINC1 | ALDH1A1 3106/4885KDM4E 4027/4885HPGD 960/4885 |
| US-20160046585-A1 | HALOGENOPYRAZOLES AS INHIBITORS OF THROMBIN | F2, TFPI, SERPINC1 | ALDH1A1 3106/4885KDM4E 4027/4885HPGD 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.