Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105878 | 0.81 | NR4A2 (0.44) | NR4A2TSHRLMNAALDH1A1HSD17B10 | |
| SCHEMBL10362667 | 0.81 | NR4A2 (0.44) | NR4A2TSHRLMNAALDH1A1HSD17B10 | |
| SCHEMBL10067848 | 0.79 | ALDH1A1 (0.57) | TSHRLMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL10067845 | 0.78 | ALDH1A1 (0.49) | TSHRLMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL524457 | 0.77 | LMNA (0.53) | NR4A2TSHRLMNAALDH1A1HSD17B10 | |
| SCHEMBL29047133 | 0.77 | CYP1A2 (0.49) | LMNAPOLBMAPTKMT2AMEN1 | |
| SCHEMBL29702037 | 0.77 | TSHR (0.63) | NR4A2TSHRLMNAALDH1A1HSD17B10 | |
| Dimethyl Phthalate SCHEMBL28079217 | 0.77 | TSHR (0.63) | NR4A2TSHRLMNAALDH1A1HSD17B10 | |
| SCHEMBL101601 | 0.77 | TSHR (0.63) | NR4A2TSHRLMNAALDH1A1HSD17B10 | |
| SCHEMBL16599381 | 0.76 | POLB (0.55) | NR4A2TSHRLMNAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014143960-A1 | TETRAHYDROISOQUINOLIN-2-YL-(QUINAZOLIN-4-YL) METHANONE COMPOUNDS AS CANCER CELL GROWTH INHIBITORS | REXAHN PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |