Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.54 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16076048 | 0.92 | TRPC5 (0.64) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL16076245 | 0.89 | SMN1; SMN2 (0.60) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL19505263 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL16028333 | 0.86 | TRPC5 (0.68) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL16028585 | 0.85 | TRPC5 (0.67) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL16364237 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL16076034 | 0.84 | TRPC5 (0.66) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL19375229 | 0.84 | TRPC5 (0.66) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL16028066 | 0.84 | TRPC5 (0.68) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 | |
| SCHEMBL16076244 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2TRPC4TRPC5KCNH2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969736-B2 | Substituted xanthines and methods of use thereof | HYDRA BIOSCIENCES, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-26 | — | — | US | disclosed |
| US-20160237089-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. | 2016-08-18 | — | — | US | disclosed |
| US-20140275071-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305910-A1 | Substituted Xanthines and Methods of Use Thereof | TRPC5, TRPC7, TRPC4 | SMN1; SMN2 1307/4885TRPC4 3/4885TRPC5 1/4885 |
| US-20140275071-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | TRPC5, TRPC7, TRPC4 | SMN1; SMN2 1307/4885TRPC4 3/4885TRPC5 1/4885 |
| US-20160237089-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | TRPC5, TRPC7, TRPC4 | SMN1; SMN2 1307/4885TRPC4 3/4885TRPC5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.