Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.55 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375252 | 0.91 | KMT2A (0.52) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16028333 | 0.89 | TRPC5 (0.68) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16076245 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16028585 | 0.86 | TRPC5 (0.67) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16076034 | 0.86 | TRPC5 (0.66) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL19375229 | 0.86 | TRPC5 (0.66) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16028066 | 0.85 | TRPC5 (0.68) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16363992 | 0.85 | MAPK1 (0.47) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16076246 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT | |
| SCHEMBL16363972 | 0.84 | TRPC4 (0.65) | SMN1; SMN2TRPC4TRPC5KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014143799-A9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-12-24 | — | — | WO | disclosed |