Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.54 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834595 | 0.90 | TRPC5 (0.65) | NPSR1TRPC4TRPC5KCNH2TP53 | |
| SCHEMBL18834900 | 0.89 | PCSK9 (0.57) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16028038 | 0.88 | RAB9A (0.57) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16076076 | 0.87 | PCSK9 (0.55) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16028224 | 0.86 | TRPC5 (0.64) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16028394 | 0.84 | TRPC4 (0.59) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16028572 | 0.84 | TRPC4 (0.69) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16028099 | 0.84 | PCSK9 (0.52) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16076082 | 0.83 | TRPC5 (0.58) | PCSK9NPSR1TRPC4TRPC5KCNH2 | |
| SCHEMBL16076111 | 0.83 | TRPC5 (0.58) | PCSK9NPSR1TRPC4TRPC5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275071-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-20140275071-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, INC. (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275071-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | TRPC5, TRPC7, TRPC4 | PCSK9 1865/4885NPSR1 836/4885TRPC4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.