SCHEMBL16076972

SCHEMBL16076972

O=C(/C=C/c1ccc([N+](=O)[O-])c(OCc2ccccc2)c1)c1ccccc1O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.53
PTGS1 P23219 2/20 0.53
PTGS2 P35354 2/20 0.53
ACHE P22303 1/20 0.53
ABCG2 Q9UNQ0 1/20 0.53
BACE1 P56817 1/20 0.52
MAOA P21397 2/20 0.52
HSP90AA1 P07900 1/20 0.52
APP P05067 1/20 0.52
MAPT P10636 3/20 0.50
KDM4E B2RXH2 3/20 0.50
MAPK1 P28482 2/20 0.50
KMT2A Q03164 2/20 0.50
GAA P10253 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
MYOC Q99972 1/20 0.50
CYSLTR2 Q9NS75 1/20 0.49
CYSLTR1 Q9Y271 1/20 0.49
ALDH1A1 P00352 2/20 0.49
MEN1 O00255 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25221692 1.00 MAOB (0.53) MAOBPTGS1PTGS2ACHEABCG2
SCHEMBL16076970 0.92 CTSV (0.56) MAOBPTGS1PTGS2ACHEABCG2
SCHEMBL9380836 0.86 KDM4E (0.63) BACE1APPKDM4EALDH1A1HPGD
SCHEMBL9380841 0.86 KDM4E (0.63) BACE1APPKDM4EALDH1A1HPGD
SCHEMBL17509394 0.86 MAOB (0.64) MAOBPTGS1PTGS2ACHEABCG2
SCHEMBL17509393 0.86 MAOB (0.64) MAOBPTGS1PTGS2ACHEABCG2
SCHEMBL30383635 0.84 MAOB (0.55) MAOBPTGS1PTGS2ACHEABCG2
SCHEMBL16079230 0.84 MAOB (0.55) MAOBPTGS1PTGS2ACHEABCG2
SCHEMBL9380318 0.84 KDM4E (0.55) BACE1APPKDM4EALDH1A1HPGD
SCHEMBL9380325 0.84 KDM4E (0.55) BACE1APPKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-20140275156-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF NEUPROTECT PTY LTD (AU) 2014-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAOB 1004/4885PTGS1 522/4885PTGS2 704/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885PTGS1 180/4885PTGS2 330/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAOB 2435/4885PTGS1 180/4885PTGS2 330/4885
US-20140275156-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF BAX, MAPKAPK2, MAPK6 MAOB 1003/4885PTGS1 1050/4885PTGS2 1086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.