Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 3/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 7/20 | 0.32 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16079591 | 0.78 | LMNA (0.34) | LMNAALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL14087874 | 0.75 | MAPT (0.34) | LMNAALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL11623043 | 0.74 | AR (0.44) | LMNAKDM4EPRKDCPIK3CAPIK3CB | |
| SCHEMBL5069635 | 0.70 | LMNA (0.34) | LMNAALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL27793746 | 0.69 | LMNA (0.43) | LMNAALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL11622794 | 0.69 | ALDH1A1 (0.44) | ALDH1A1KDM4EPRKDCPIK3CAPIK3CB | |
| SCHEMBL11625392 | 0.68 | AOC3 (0.39) | LMNAALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL28305687 | 0.67 | MTOR (0.38) | LMNAALDH1A1KDM4EHPGDPRKDC | |
| SCHEMBL16501134 | 0.67 | LMNA (0.38) | LMNAKMOALDH1A1ALOX15HSD17B10 | |
| SCHEMBL16088305 | 0.67 | GAA (0.33) | LMNAALDH1A1ALOX15HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359380-B2 | DNA-PK inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-07 | — | — | US | disclosed |
| US-20140275059-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275059-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | LMNA 484/4885KMO 2181/4885ALDH1A1 2935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.