Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | NT5E | P21589 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16579288 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL20419174 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL440329 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL114918 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL10159432 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL24359132 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL972927 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL3741590 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL22559823 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL7168927 | 0.86 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10231986-B2 | Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV | IDENIX PHARMACEUTICALS LLC (US) | 2019-03-19 | — | — | US | disclosed |
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | UNIVERSITE DE MONTPELLIER (FR) | 2016-04-28 | — | — | US | disclosed |
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | UNIVERSITE DE MONTPELLIER (FR) | 2016-04-28 | — | — | US | disclosed |
| WO-2014160484-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. | 2014-09-18 | — | — | US | disclosed |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10231986-B2 | Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV | PNP, RNGTT, NSUN2 | LMNA 603/4885NT5E 232/4885HIF1A 3443/4885 |
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | PNP, RNGTT, NSUN2 | LMNA 604/4885NT5E 243/4885HIF1A 3385/4885 |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | PNP, RNGTT, NSUN2 | LMNA 604/4885NT5E 243/4885HIF1A 3385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.