Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | ROR1 | Q01973 | 8/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.45 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.45 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16084979 | 0.90 | RIPK1 (0.46) | RIPK1RIPK2RIPK3ABL1 | |
| SCHEMBL16084969 | 0.89 | RIPK1 (0.75) | RIPK1RIPK2RIPK3ABL1KCNH2 | |
| SCHEMBL16084960 | 0.86 | RIPK1 (0.67) | RIPK1RIPK2RIPK3ABL1KCNH2 | |
| SCHEMBL16084950 | 0.86 | RIPK1 (0.78) | RIPK1RIPK2RIPK3ABL1KCNH2 | |
| SCHEMBL16084946 | 0.85 | RIPK1 (0.77) | RIPK1RIPK2RIPK3ABL1KCNH2 | |
| SCHEMBL16084985 | 0.79 | RIPK1 (0.63) | RIPK1RIPK2RIPK3ABL1KCNH2 | |
| SCHEMBL16084986 | 0.79 | RIPK1 (0.60) | RIPK1RIPK2RIPK3ABL1 | |
| SCHEMBL16084959 | 0.78 | RIPK1 (0.59) | RIPK1RIPK2RIPK3ABL1KCNH2 | |
| SCHEMBL19225534 | 0.76 | RIPK1 (0.58) | RIPK1RIPK2RIPK3ABL1KCNH2 | |
| SCHEMBL16084951 | 0.75 | RIPK1 (0.59) | RIPK1RIPK2RIPK3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725452-B2 | Substituted indoles and pyrroles as RIP kinase inhibitors | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-08 | — | — | US | disclosed |
| US-20160024098-A1 | HYBRID NECROPTOSIS INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-28 | — | — | US | disclosed |
| US-20140323489-A1 | HYBRID NECROPTOSIS INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-10-30 | — | — | US | disclosed |
| WO-2014145022-A1 | HYBRID NECROPTOSIS INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323489-A1 | HYBRID NECROPTOSIS INHIBITORS | RIPK3, RIPK1, RIPK4 | RIPK1 2/4885RIPK2 4/4885RIPK3 1/4885 |
| US-20160024098-A1 | HYBRID NECROPTOSIS INHIBITORS | RIPK3, RIPK1, RIPK4 | RIPK1 2/4885RIPK2 4/4885RIPK3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.