Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.58 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 11/20 | 0.47 |
| ▸ | ROR1 | Q01973 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.44 |
| ▸ | EPHB3 | P54753 | 3/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.44 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.44 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16084959 | 0.89 | RIPK1 (0.59) | RIPK1RIPK2RIPK3ABL1ROR1 | |
| SCHEMBL16084969 | 0.87 | RIPK1 (0.75) | RIPK1RIPK2RIPK3ABL1ROR1 | |
| SCHEMBL16084946 | 0.84 | RIPK1 (0.77) | RIPK1RIPK2RIPK3ABL1ROR1 | |
| SCHEMBL16084960 | 0.81 | RIPK1 (0.67) | RIPK1RIPK2RIPK3ABL1ROR1 | |
| SCHEMBL16204134 | 0.79 | RIPK1 (0.47) | RIPK1RIPK2RIPK3ABL1KIT | |
| SCHEMBL16084985 | 0.77 | RIPK1 (0.63) | RIPK1RIPK2RIPK3ABL1CYP3A4 | |
| SCHEMBL16084986 | 0.76 | RIPK1 (0.60) | RIPK1RIPK2RIPK3ABL1 | |
| SCHEMBL16084945 | 0.76 | RIPK1 (0.59) | RIPK1RIPK2RIPK3ABL1ROR1 | |
| SCHEMBL19225593 | 0.75 | RIPK1 (0.48) | RIPK1RIPK2RIPK3ABL1CYP3A4 | |
| SCHEMBL16084958 | 0.74 | RIPK1 (0.92) | RIPK1RIPK2RIPK3ABL1ROR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725452-B2 | Substituted indoles and pyrroles as RIP kinase inhibitors | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2017-08-08 | — | — | US | disclosed |