Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | NOD1 | Q9Y239 | 13/20 | 0.79 |
| ▸ | TNF | P01375 | 11/20 | 0.79 |
| ▸ | MEN1 | O00255 | 6/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.79 |
| ▸ | RAB9A | P51151 | 6/20 | 0.79 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.79 |
| ▸ | NOD2 | Q9HC29 | 9/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.73 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16085384 | 0.93 | NOD1 (0.75) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL16085389 | 0.92 | NOD1 (0.73) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL16263700 | 0.90 | SMN1; SMN2 (0.89) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL16085655 | 0.89 | NOD1 (0.73) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL16085403 | 0.89 | SMN1; SMN2 (1.00) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL16060510 | 0.88 | NOD1 (1.00) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL21657710 | 0.85 | HIF1A (1.00) | SMN1; SMN2MEN1KMT2ARAB9AMAPT | |
| SCHEMBL16062262 | 0.85 | NOD1 (0.80) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL16085532 | 0.83 | NOD1 (0.72) | SMN1; SMN2KDM4ENOD1TNFMEN1 | |
| SCHEMBL8769811 | 0.82 | RAB9A (0.83) | SMN1; SMN2MEN1KMT2ARAB9ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145642-A9 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-11-13 | — | — | WO | disclosed |
| WO-2014145642-A2 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-18 | — | — | WO | disclosed |
| US-8728631-B2 | Dendrimer compound and organic luminescent device employing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-05-20 | — | — | US | disclosed |