Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16087384 | 0.87 | L3MBTL1 (0.58) | LMNAMEN1KMT2AMAPTHSD11B1 | |
| SCHEMBL16087283 | 0.83 | L3MBTL1 (0.63) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL2225804 | 0.82 | MAPT (0.56) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL16087252 | 0.82 | SCN9A (0.51) | LMNAKMT2AMAPTATMSMN1; SMN2 | |
| SCHEMBL1946969 | 0.82 | L3MBTL1 (0.68) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL1429673 | 0.82 | L3MBTL1 (0.70) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL16087187 | 0.81 | PKM (0.54) | LMNAMAPTATMSMN1; SMN2GAA | |
| SCHEMBL16087385 | 0.81 | L3MBTL1 (0.66) | LMNAMEN1KMT2AMAPTHSD11B1 | |
| SCHEMBL17953068 | 0.81 | KMT2A (0.58) | LMNAMEN1KMT2APOLBMAPT | |
| SCHEMBL1429810 | 0.81 | MEN1 (0.52) | LMNAMEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533782-B1 | PIPERAZINE DERIVATIVES FOR BLOCKING Cav2.2 CALCIUM CHANNELS | CONVERGENCE PHARMACEUTICALS (GB) | 2014-09-24 | — | — | EP | claimed |