Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | LOX | P28300 | 2/20 | 0.44 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.44 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18770518 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL420793 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL17290426 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL17290523 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL17290346 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2PTGS1 | |
| SCHEMBL28585189 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL17290955 | 0.79 | LOX (0.45) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL18770503 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL17290822 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 | |
| SCHEMBL11047547 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1MAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3490975-B1 | O-SUBSTITUTED HYDROXAMIC ACIDS | UNIV JOHNS HOPKINS (US) | 2021-05-05 | — | — | EP | disclosed |
| US-10913728-B2 | O-substituted hydroxamic acids | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-02-09 | — | — | US | disclosed |
| EP-3490975-A1 | O-SUBSTITUTED HYDROXAMIC ACIDS | The Johns Hopkins University (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20190161464-A1 | O-SUBSTITUTED HYDROXAMIC ACIDS | NATIONAL SCIENCE FOUNDATION | 2019-05-30 | — | — | US | disclosed |
| WO-2018022899-A1 | O-SUBSTITUTED HYDROXAMIC ACIDS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-02-01 | — | — | WO | disclosed |
| US-20170050947-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | THE JOHNS HOPKINS UNIVERSITY | 2017-02-23 | — | — | US | disclosed |
| US-9181213-B2 | Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-11-10 | — | — | US | disclosed |
| US-20140275134-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | NATIONAL SCIENCE FOUNDATION | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050947-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | HMOX1, HMOX2, HPGD | SMN1; SMN2 478/4885ALDH1A1 515/4885MAPT 3459/4885 |
| US-10913728-B2 | O-substituted hydroxamic acids | HAAO, HAO2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | SMN1; SMN2 1466/4885ALDH1A1 1193/4885MAPT 4030/4885 |
| US-20190161464-A1 | O-SUBSTITUTED HYDROXAMIC ACIDS | HAAO, HAO2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | SMN1; SMN2 1466/4885ALDH1A1 1193/4885MAPT 4030/4885 |
| US-20140275134-A1 | MELDRUM'S ACID, BARBITURIC ACID AND PYRAZOLONE DERIVATIVES SUBSTITUTED WITH HYDROXYLAMINE AS HNO DONORS | HMOX1, HMOX2, HPGD | SMN1; SMN2 478/4885ALDH1A1 515/4885MAPT 3459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.