SCHEMBL16091749

SCHEMBL16091749

CCc1cc(CC)c2sccc2c1N

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ TERT O14746 1/20 0.40
▸ HTT P42858 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ LMNA P02545 1/20 0.34
▸ DYRK1A Q13627 1/20 0.33
▸ PARP1 P09874 1/20 0.32
▸ ADORA1 P30542 3/20 0.31
▸ ADORA3 P0DMS8 2/20 0.31
▸ ADORA2A P29274 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ NEK1 Q96PY6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15629835 0.86 TERT (0.38) TERTHTTPOLBLMNADYRK1A
SCHEMBL21913653 0.74 LMNA (0.35) LMNAADORA1ADORA3ADORA2A
SCHEMBL16091753 0.73 TERT (0.33) TERTALDH1A1
SCHEMBL10085119 0.70 TERT (0.48) TERTLMNADYRK1APARP1ADORA1
SCHEMBL17208942 0.69 ADORA1 (0.33) LMNAADORA1ADORA3ADORA2AMAPT
SCHEMBL4415789 0.68 TERT (0.52) TERTDYRK1AADORA1ADORA2AALDH1A1
SCHEMBL27612200 0.67 HTT (0.50) HTTPOLBALDH1A1MAPT
SCHEMBL10745865 0.66 CES1 (0.36) TERTPOLBPARP1MAPTNEK1
SCHEMBL21913655 0.66 ACE2 (0.36) TERTLMNAADORA1ADORA3ADORA2A
SCHEMBL15629822 0.66 POLB (0.34) HTTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9340521-B2 Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives GREEN CROSS CORPORATION (KR) 2016-05-17 — — US disclosed
US-20140274918-A1 METHOD FOR DUAL INHIBITION OF SGLT1 AND SGLT2 USING DIPHENYLMETHANE DERIVATIVES GREEN CROSS CORPORATION (KR) 2014-09-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140274918-A1 METHOD FOR DUAL INHIBITION OF SGLT1 AND SGLT2 USING DIPHENYLMETHANE DERIVATIVES SLC5A2, SLC5A1, SLC10A2 TERT 4595/4885HTT 3125/4885POLB 4766/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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