Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15366862 | 1.00 | MDM2 (0.44) | MDM2CYP3A4CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11232538 | 0.81 | GRIN2D (0.55) | CYP3A4HSD17B10ALDH1A1LMNANPSR1 | |
| SCHEMBL15094415 | 0.81 | GRIN2D (0.55) | CYP3A4HSD17B10ALDH1A1LMNANPSR1 | |
| SCHEMBL2801168 | 0.80 | LMNA (0.53) | CYP3A4CYP1A2MAPK1HIF1AABCC9 | |
| SCHEMBL2801166 | 0.80 | LMNA (0.53) | CYP3A4CYP1A2MAPK1HIF1AABCC9 | |
| SCHEMBL4679717 | 0.80 | LMNA (0.53) | CYP3A4CYP1A2MAPK1HIF1AABCC9 | |
| SCHEMBL9701789 | 0.79 | PEPD (0.48) | CYP3A4NFKB1MAPK1ALDH1A1LMNA | |
| SCHEMBL1983930 | 0.78 | NPC1 (0.50) | CYP3A4CYP1A2CYP2C9ALOX15MAPK1 | |
| SCHEMBL1983932 | 0.78 | NPC1 (0.50) | CYP3A4CYP1A2CYP2C9ALOX15MAPK1 | |
| SCHEMBL11236640 | 0.78 | GRIN2D (0.58) | CYP3A4CYP1A2CYP2C19ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283953-B | Indoline compound containing thiazole structure, and preparation method and application thereof | 沈阳药科大学 | 2024-02-02 | — | — | CN | disclosed |
| US-20240016953-A1 | TARGETED DELIVERY OF NICOTINAMINDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY INHIBITORS | SEAGEN INC (US) | 2024-01-18 | — | — | US | disclosed |
| CN-116283953-A | Indoline compound containing thiazole structure, and preparation method and application thereof | 沈阳药科大学 | 2023-06-23 | — | — | CN | disclosed |
| US-20220257781-A1 | POLYMER CONJUGATE BONDED TO TERTIARY AMINE COMPOUND OR IMINE COMPOUND AND PRODUCTION METHOD THEREFOR | SEIKAGAKU CORPORATION (JP) | 2022-08-18 | — | — | US | disclosed |
| US-20200138964-A1 | TERTIARY AMINE COMPOUND OR IMINE COMPOUND-POLYMER CONJUGATE AND PRODUCTION METHOD THEREFOR | SEIKAGAKU CORPORATION (JP) | 2020-05-07 | — | — | US | disclosed |
| US-9676721-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2017-06-13 | — | — | US | disclosed |
| US-20130295051-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO HEALTH, INC. | 2013-11-07 | — | — | US | disclosed |
| EP-2611778-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031199-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| EP-1507760-A1 | CYANOGUANIDINE PRODRUGS | Leo Pharma A/S (DK) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097601-A1 | CYANOGUANIDINE PRODRUGS | LEO PHARMA A/S (DK) | 2003-11-27 | — | — | WO | disclosed |
| WO-2002042276-A1 | QUARTERNARY PROFORMS OF TERTIARY AMINE CONTAINING COMPOUNDS | LEO PHARMA A/S (DK) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240016953-A1 | TARGETED DELIVERY OF NICOTINAMINDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY INHIBITORS | NAMPT, NAPRT, NNMT | MDM2 3367/4885CYP3A4 4861/4885CYP1A2 4818/4885 |
| US-20220257781-A1 | POLYMER CONJUGATE BONDED TO TERTIARY AMINE COMPOUND OR IMINE COMPOUND AND PRODUCTION METHOD THEREFOR | ODC1, DOHH, SMYD2 | MDM2 3240/4885CYP3A4 1937/4885CYP1A2 3805/4885 |
| US-20130295051-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | MDM2 4871/4885CYP3A4 2406/4885CYP1A2 2312/4885 |
| US-20200138964-A1 | TERTIARY AMINE COMPOUND OR IMINE COMPOUND-POLYMER CONJUGATE AND PRODUCTION METHOD THEREFOR | SOAT1, SLC7A1, ODC1 | MDM2 3034/4885CYP3A4 1037/4885CYP1A2 2394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.