Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15777787 | 0.85 | RIPK1 (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16094136 | 0.81 | THRA (0.38) | — | |
| SCHEMBL17418124 | 0.79 | SCN9A (0.37) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17418122 | 0.79 | SCN9A (0.37) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17433246 | 0.74 | SCN9A (0.35) | — | |
| SCHEMBL16094368 | 0.74 | CHUK (0.34) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17418102 | 0.74 | SCN9A (0.35) | — | |
| SCHEMBL17418103 | 0.74 | SCN9A (0.35) | — | |
| SCHEMBL16094355 | 0.68 | CNR2 (0.36) | — | |
| SCHEMBL17418003 | 0.68 | SCN9A (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968280-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |