Amcinonide

SCHEMBL16093940

CC(=O)OCC(=O)[C@@]12OC3(CCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C.C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Amcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	8/20	0.85

▸	CYP3A4	P08684	8/20	0.85

▸	HIF1A	Q16665	8/20	0.85

▸	LMNA	P02545	5/20	0.85

▸	PGR	P06401	5/20	0.85

▸	CNR1	P21554	2/20	0.85

▸	NPSR1	Q6W5P4	2/20	0.85

▸	KCNH2	Q12809	1/20	0.85

▸	USP2	O75604	1/20	0.85

▸	MAPT	P10636	1/20	0.85

▸	CYP2C9	P11712	1/20	0.72

▸	TBXA2R	P21731	1/20	0.72

▸	SMN1; SMN2	Q16637	1/20	0.72

▸	HSD17B10	Q99714	3/20	0.68

▸	NFKB1	P19838	3/20	0.68

▸	TSHR	P16473	2/20	0.68

▸	AR	P10275	2/20	0.68

▸	PMP22	Q01453	2/20	0.68

▸	MEN1	O00255	1/20	0.68

▸	CYP2D6	P10635	1/20	0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Amcinonide SCHEMBL13026154	0.92	HIF1A (1.00)	CYP3A4HIF1ANR3C1LMNAPGR
Amcinonide SCHEMBL5488922	0.92	HIF1A (1.00)	CYP3A4HIF1ANR3C1LMNAPGR
Amcinonide SCHEMBL21051752	0.92	HIF1A (1.00)	CYP3A4HIF1ANR3C1LMNAPGR
Amcinonide SCHEMBL4720	0.92	HIF1A (1.00)	CYP3A4HIF1ANR3C1LMNAPGR
Amcinonide SCHEMBL1649481	0.92	HIF1A (1.00)	CYP3A4HIF1ANR3C1LMNAPGR
Amcinonide SCHEMBL12396698	0.92	HIF1A (1.00)	CYP3A4HIF1ANR3C1LMNAPGR
Amcinonide SCHEMBL13723413	0.91	HIF1A (0.70)	CYP3A4HIF1ANR3C1LMNAPGR
Fluocinonide SCHEMBL28122375	0.89	HIF1A (0.75)	CYP3A4HIF1ANR3C1LMNAPGR
Fluocinonide SCHEMBL3475945	0.89	HIF1A (0.75)	CYP3A4HIF1ANR3C1LMNAPGR
Betamethasone Acetate SCHEMBL3681474	0.88	HIF1A (0.94)	CYP3A4HIF1ANR3C1LMNAPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2968368-A2	CRANIAL DELIVERY OF PHARMACEUTICALS	Glia LLC (US)	2016-01-20	—	—	EP	disclosed
WO-2014152385-A2	CRANIAL DELIVERY OF PHARMACEUTICALS	GLIA, LLC (US)	2014-09-25	—	—	WO	disclosed