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Sugi Predict / Compounds / Fluocinonide

Fluocinonide

Fluocinonide

SCHEMBL28122375

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nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 5/20 0.75
▸ HIF1A Q16665 11/20 0.75
▸ LMNA P02545 7/20 0.75
▸ PGR P06401 5/20 0.75
▸ AR P10275 3/20 0.75
▸ ALDH1A1 P00352 2/20 0.75
▸ MEN1 O00255 2/20 0.75
▸ KMT2A Q03164 2/20 0.75
▸ CYP3A4 P08684 8/20 0.67
▸ MAPT P10636 3/20 0.67
▸ HSD17B10 Q99714 3/20 0.67
▸ CNR1 P21554 2/20 0.67
▸ SMN1; SMN2 Q16637 2/20 0.67
▸ TDP1 Q9NUW8 1/20 0.67
▸ CYP2C9 P11712 1/20 0.67
▸ KDM4E B2RXH2 1/20 0.67
▸ MAPK1 P28482 1/20 0.67
▸ NR1I2 O75469 1/20 0.67
▸ TBXA2R P21731 1/20 0.67
▸ NPSR1 Q6W5P4 2/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluocinonide SCHEMBL3475945 1.00 HIF1A (0.75) HIF1ALMNANR3C1PGRAR
Fluocinolone Acetonide SCHEMBL5501859 0.94 HIF1A (0.77) HIF1ALMNANR3C1PGRAR
Fluocinonide SCHEMBL11325670 0.93 HIF1A (0.82) HIF1ALMNANR3C1PGRAR
Amcinonide SCHEMBL16093940 0.89 CYP3A4 (0.85) HIF1ALMNANR3C1PGRAR
Amcinonide SCHEMBL13723413 0.89 HIF1A (0.70) HIF1ALMNANR3C1PGRAR
Fluocinonide SCHEMBL11596245 0.88 NR3C1 (0.68) HIF1ALMNANR3C1PGRAR
Triamcinolone Acetonide SCHEMBL28103100 0.88 CYP3A4 (0.87) HIF1ALMNANR3C1PGRAR
Fluocinonide SCHEMBL28089918 0.88 NR3C1 (0.94) HIF1ALMNANR3C1PGRAR
Fluocinonide SCHEMBL2863286 0.88 HIF1A (0.58) HIF1ALMNANR3C1PGRAR
SCHEMBL15975096 0.87 HIF1A (0.87) HIF1ALMNANR3C1PGRAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101890167-B The sustained release pharmaceutical composition that can conveniently implant 拉姆斯科股份有限公司 2017-03-01 — — CN disclosed
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