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Amcinonide

Amcinonide

SCHEMBL13723413

CC(=O)OCC(=O)[C@@]12OC3(CCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]12C.C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C(Cl)=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Amcinonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 6/20 0.70
▸ HIF1A Q16665 8/20 0.70
▸ CYP3A4 P08684 8/20 0.70
▸ PGR P06401 6/20 0.70
▸ LMNA P02545 5/20 0.70
▸ CNR1 P21554 2/20 0.70
▸ NPSR1 Q6W5P4 2/20 0.70
▸ MAPT P10636 2/20 0.70
▸ KCNH2 Q12809 1/20 0.70
▸ USP2 O75604 1/20 0.70
▸ TBXA2R P21731 2/20 0.60
▸ CYP2C9 P11712 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.60
▸ AR P10275 4/20 0.59
▸ MEN1 O00255 2/20 0.59
▸ KMT2A Q03164 2/20 0.59
▸ ALDH1A1 P00352 1/20 0.59
▸ GAA P10253 1/20 0.59
▸ CHRM1 P11229 1/20 0.59
▸ ADRA1A P35348 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amcinonide SCHEMBL16093940 0.91 CYP3A4 (0.85) HIF1ACYP3A4NR3C1PGRLMNA
Fluocinonide SCHEMBL28122375 0.89 HIF1A (0.75) HIF1ACYP3A4NR3C1PGRLMNA
Fluocinonide SCHEMBL3475945 0.89 HIF1A (0.75) HIF1ACYP3A4NR3C1PGRLMNA
Fluocinolone Acetonide SCHEMBL5501859 0.84 HIF1A (0.77) HIF1ACYP3A4NR3C1PGRLMNA
Amcinonide SCHEMBL21051752 0.84 HIF1A (1.00) HIF1ACYP3A4NR3C1PGRLMNA
Amcinonide SCHEMBL12396698 0.84 HIF1A (1.00) HIF1ACYP3A4NR3C1PGRLMNA
Amcinonide SCHEMBL5488922 0.84 HIF1A (1.00) HIF1ACYP3A4NR3C1PGRLMNA
Amcinonide SCHEMBL13026154 0.84 HIF1A (1.00) HIF1ACYP3A4NR3C1PGRLMNA
Amcinonide SCHEMBL4720 0.84 HIF1A (1.00) HIF1ACYP3A4NR3C1PGRLMNA
Amcinonide SCHEMBL1649481 0.84 HIF1A (1.00) HIF1ACYP3A4NR3C1PGRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103717597-B Heterocyclic compounds as kinase inhibitors 原真股份有限公司 2017-07-04 — — CN disclosed
CN-103492389-B Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases 原真股份有限公司 2016-09-14 — — CN disclosed
EP-2699572-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS Origenis GmbH (DE) 2014-02-26 — — EP disclosed
EP-2699579-A1 PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS Origenis GmbH (DE) 2014-02-26 — — EP disclosed
WO-2012143143-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2012-10-26 — — WO disclosed
WO-2012143144-A1 PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2012-10-26 — — WO disclosed
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