Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013758 | 0.83 | MAPK14 (0.49) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL23723738 | 0.83 | MAPK14 (0.49) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL29013146 | 0.81 | SMN1; SMN2 (0.54) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL10819320 | 0.80 | L3MBTL1 (0.61) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL16011825 | 0.80 | MAPK14 (0.46) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL8320729 | 0.80 | MAPK14 (0.46) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL16012000 | 0.80 | MAPK14 (0.46) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL1007717 | 0.80 | MAOB (0.45) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL17224562 | 0.78 | MAPT (0.56) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL30666961 | 0.78 | MAPT (0.56) | MAPK14LTA4HMAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968280-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |