Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013758 | 1.00 | MAPK14 (0.49) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL31517959 | 0.83 | L3MBTL1 (0.51) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL8320729 | 0.83 | MAPK14 (0.46) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL10819320 | 0.83 | L3MBTL1 (0.61) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL16094113 | 0.83 | MAPK14 (0.49) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL30666961 | 0.80 | MAPT (0.56) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL30666902 | 0.80 | POLB (0.44) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL23723810 | 0.80 | ACACB (0.46) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL17224562 | 0.80 | MAPT (0.56) | MAPK14LTA4HMAPTMAPK1TDP1 | |
| SCHEMBL30014456 | 0.80 | ACACB (0.46) | MAPK14LTA4HMAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100124-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| CN-115427109-A | Heterocyclic compounds as dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-12-02 | — | — | CN | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |