Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.43 |
| ▸ | KDM5A | P29375 | 2/20 | 0.43 |
| ▸ | KDM5C | P41229 | 2/20 | 0.43 |
| ▸ | KDM4B | O94953 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 3/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604563 | 0.91 | KDM5B (0.41) | KDM4CKDM5BKDM5AKDM5CKDM4B | |
| SCHEMBL16095379 | 0.90 | KDM4C (0.47) | KDM4CKDM5BKDM5AKDM5CKDM4B | |
| SCHEMBL17604506 | 0.90 | KDM4C (0.54) | KDM4CKDM5BKDM5AKDM5CKDM4B | |
| SCHEMBL16095181 | 0.82 | KDM5B (0.44) | KDM4CKDM5BKDM5CKDM4BKDM4A | |
| SCHEMBL16095166 | 0.81 | PARP1 (0.45) | KDM4CKDM5BKDM5CKDM4BKDM4A | |
| SCHEMBL17604519 | 0.81 | KRAS (0.41) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL17604570 | 0.80 | MAPT (0.38) | KDM4CKDM5BKDM5AKDM4AP2RX7 | |
| SCHEMBL16095079 | 0.77 | ADORA2A (0.39) | KDM4CPOLBKDM4ELMNAMAPT | |
| SCHEMBL16095624 | 0.76 | KDM4C (0.56) | KDM4CKDM5BKDM5AKDM5CKDM4B | |
| SCHEMBL16095346 | 0.76 | KDM4C (0.52) | KDM4CKDM5BKDM5AKDM5CKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |