Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16094975 | 0.91 | KDM4C (0.43) | KDM5BKDM4BKDM5CALDH1A1KDM4C | |
| SCHEMBL16095379 | 0.84 | KDM4C (0.47) | KDM5BKDM4BKDM5CKDM4CKDM5A | |
| SCHEMBL16095166 | 0.82 | PARP1 (0.45) | KDM5BKDM4BKDM5CKDM4CPRKD1 | |
| SCHEMBL17604506 | 0.81 | KDM4C (0.54) | KDM5BKDM4BKDM5CKDM4CKDM5A | |
| SCHEMBL17604574 | 0.81 | PHF8 (0.37) | KDM4CPHF8MEN1KMT2A | |
| SCHEMBL16095181 | 0.80 | KDM5B (0.44) | KDM5BKDM4BKDM5CKDM4CPARP1 | |
| SCHEMBL17604542 | 0.79 | PHF8 (0.39) | KDM4CPHF8MEN1KMT2APIM1 | |
| SCHEMBL16095813 | 0.78 | PHF8 (0.39) | L3MBTL1KDM4CPHF8POLB | |
| SCHEMBL16095163 | 0.76 | KDM4C (0.62) | KDM5BKDM4CKDM5APHF8 | |
| SCHEMBL17604562 | 0.74 | PHF8 (0.60) | KDM5BKDM4CKDM5APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |